bis-(2-chlorophenyl)methylamine

Base Information

• Chemical Name: bis-(2-chlorophenyl)methylamine
• CAS No.: 439094-10-7
• Molecular Formula: C₁₃H₁₁Cl₂N
• Molecular Weight: 252.143
• Mol file: 439094-10-7.mol

Synonyms:bis-(2-chlorophenyl)methylamine

Chemical Property of bis-(2-chlorophenyl)methylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis-(2-chlorophenyl)methylamine

There total 5 articles about bis-(2-chlorophenyl)methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

bis(2-chlorophenyl)methanone oxime → bis-(2-chlorophenyl)methylamine (439094-10-7)

Guidance literature:

With ammonium acetate; ammonium hydroxide; zinc; In ethanol; for 4h; Heating;

DOI:10.1021/jm0111088

Reference yield:

2,2'-dichlorobenzophenone (5293-97-0) → bis-(2-chlorophenyl)methylamine (439094-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / hydroxylamine hydrochloride; pyridine / 100 °C

2: 99 percent / aq. ammonia; ammonium acetate; zinc / ethanol / 4 h / Heating

With pyridine; ammonium acetate; ammonium hydroxide; hydroxylamine hydrochloride; zinc; In ethanol;

DOI:10.1021/jm0111088

Reference yield:

2-chloro-benzaldehyde (89-98-5) → bis-(2-chlorophenyl)methylamine (439094-10-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: magnesium; iodine / tetrahydrofuran / 1 h / 20 °C

1.2: 1 h / 20 °C

2.1: pyridinium chlorochromate / dichloromethane / 20 °C

3.1: hydroxylamine hydrochloride; pyridine / ethanol / 10 h / Reflux

4.1: ammonia; ammonium acetate; zinc / ethanol / 8 h / 50 °C / Reflux

With pyridine; hydroxylamine hydrochloride; ammonium acetate; ammonia; iodine; magnesium; pyridinium chlorochromate; zinc; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/ja408864c

upstream raw materials:

2,2'-dichlorobenzophenone

2-bromo-1-chlorobenzene

2-chloro-benzaldehyde

2,2'-dichloro-benzhydrol

Downstream raw materials:

bis-(2-chlorophenyl)methyl isothiocyanate