(Z)-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-phenylethanamide

Base Information

• Chemical Name: (Z)-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-phenylethanamide
• CAS No.: 204690-21-1
• Molecular Formula: C₁₅H₁₆N₂O₄S
• Molecular Weight: 320.369
• Mol file: 204690-21-1.mol

Synonyms:(Z)-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-phenylethanamide

Chemical Property of (Z)-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-phenylethanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-phenylethanamide

There total 4 articles about (Z)-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-phenylethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

cyanoacetanilide (621-03-4) + diethyl 2-mercaptosuccinate (23060-14-2) → (Z)-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-phenylethanamide (204690-21-1)

Guidance literature:

With potassium carbonate; In ethanol; for 5h; Heating;

DOI:10.1016/S0040-4020(03)01146-3

Reference yield: 43.0%

cyanoacetanilide (621-03-4) + diethyl 2-mercaptosuccinate (23060-14-2) → (Z)-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-phenylethanamide (204690-21-1) + {4-Oxo-2-[1-phenylcarbamoyl-meth-(E)-ylidene]-thiazolidin-5-yl}-acetic acid ethyl ester

Guidance literature:

With potassium carbonate; In ethanol; for 3.5h; Heating;

DOI:10.3987/COM-97-8094

Reference yield:

(5-ethoxycarbonylmethylidene-4-oxothiazolidin-2-ylidene)-N-phenylethanamide → (Z)-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-phenylethanamide (204690-21-1)

Guidance literature:

With water; In dimethyl sulfoxide; Mechanism; Electrochemical reaction;

DOI:10.1016/j.electacta.2011.03.007

upstream raw materials:

cyanoacetanilide

diethyl 2-mercaptosuccinate

Downstream raw materials:

(Z)-2-bromo-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-phenylethanamide

(2E,5Z)-N-phenyl (5-ethoxycarbonylmethylidene-4-oxothiazolidin-2-ylidene)ethanamide

(2Z,5Z)-N-phenyl (5-ethoxycarbonylmethylidene-4-oxothiazolidin-2-ylidene)ethanamide

(E)-2-bromo-2-(5-ethoxycarbonylmethyl-4-oxothiazolidin-2-ylidene)-N-phenylethanamide