(S)-2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutan-1-ol

Base Information

Chemical Name:(S)-2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutan-1-ol
CAS No.:1426434-48-1
Molecular Formula:C₂₁H₃₉NO₄Si
Molecular Weight:397.63
Hs Code.:

Synonyms:(S)-2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutan-1-ol

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Chemical Property of (S)-2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutan-1-ol

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Technology Process of (S)-2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutan-1-ol

There total 5 articles about (S)-2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1426434-47-0
(S)-methyl 2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutanoate

: 1426434-48-1
(S)-2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1.5h; Inert atmosphere;
DOI:10.1055/s-0032-1317931

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1426434-48-1
(S)-2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 72 h / 20 °C / Molecular sieve; Inert atmosphere

2: dmap / acetonitrile / 24 h

3: sodium tetrahydroborate; water / tetrahydrofuran / 0 - 20 °C

4: 1H-imidazole / dichloromethane / 2 h / 20 °C

5: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

With 1H-imidazole; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; water; In tetrahydrofuran; dichloromethane; acetonitrile; 1: |Ugi Condensation;
DOI:10.1055/s-0032-1317931

Reference yield:

: 1426434-43-6
(9R,11S)-methyl 7-(tert-butoxycarbonyl)-9-(3,4-dimethoxyphenyl)-12-methyl-3,8-dioxo-1-phenyl-2,4-dioxa-7,10-diazatridecane-11-carboxylate

: 1426434-48-1
(S)-2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; water / tetrahydrofuran / 0 - 20 °C

2: 1H-imidazole / dichloromethane / 2 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; water; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-0032-1317931