(S)-methyl 2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutanoate

Base Information

Chemical Name:(S)-methyl 2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutanoate
CAS No.:1426434-47-0
Molecular Formula:C₂₂H₃₉NO₅Si
Molecular Weight:425.641
Hs Code.:

Synonyms:(S)-methyl 2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutanoate

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Chemical Property of (S)-methyl 2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutanoate

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Technology Process of (S)-methyl 2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutanoate

There total 5 articles about (S)-methyl 2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1426434-44-7
(S)-methyl 2-((R)-1-(3,4-dimethoxyphenyl)-2-hydroxyethylamino)-3-methylbutanoate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1426434-47-0
(S)-methyl 2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutanoate

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1055/s-0032-1317931

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 1426434-47-0
(S)-methyl 2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 72 h / 20 °C / Molecular sieve; Inert atmosphere

2: dmap / acetonitrile / 24 h

3: sodium tetrahydroborate; water / tetrahydrofuran / 0 - 20 °C

4: 1H-imidazole / dichloromethane / 2 h / 20 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; water; In tetrahydrofuran; dichloromethane; acetonitrile; 1: |Ugi Condensation;
DOI:10.1055/s-0032-1317931

Reference yield:

: 1426434-43-6
(9R,11S)-methyl 7-(tert-butoxycarbonyl)-9-(3,4-dimethoxyphenyl)-12-methyl-3,8-dioxo-1-phenyl-2,4-dioxa-7,10-diazatridecane-11-carboxylate

: 1426434-47-0
(S)-methyl 2-((R)-2-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxyphenyl)ethylamino)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; water / tetrahydrofuran / 0 - 20 °C

2: 1H-imidazole / dichloromethane / 2 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; water; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-0032-1317931