dimethyl (2R,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

Base Information

Chemical Name:dimethyl (2R,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate
CAS No.:1312438-48-4
Molecular Formula:C₂₉H₃₃O₁₀PS
Molecular Weight:604.615
Hs Code.:

Synonyms:dimethyl (2R,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dimethyl (2R,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

Chemical Property:

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Technology Process of dimethyl (2R,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

There total 9 articles about dimethyl (2R,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312438-45-1
dimethyl (2RS,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

: 1312438-48-4
dimethyl (2R,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

: 1312438-47-3
dimethyl (2S,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

Guidance literature:: With Chiralcel OD-H; In ethanol; hexane; at 20 ℃; Product distribution / selectivity; Resolution of racemate;

Reference yield:

: 1312438-44-0
dimethyl rac-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

: 1312438-48-4
dimethyl (2R,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

: 1312438-47-3
dimethyl (2S,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

: 1312438-50-8
dimethyl (2R,4R)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

: 1312438-49-5
dimethyl (2S,4R)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)-pentanedioate

Guidance literature:: With Chiralcel OD-H; In ethanol; hexane; at 20 ℃; Product distribution / selectivity; Resolution of racemate;

Reference yield:

: 17176-77-1
Dibenzyl phosphite

: 1312438-48-4
dimethyl (2R,4S)-2-{[bis(benzyloxy)phosphoryl]methyl}-4-(tosyloxy)pentanedioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 - 90 °C

2.1: pyridine hydrogenfluoride / tetrahydrofuran / 3.5 h / 20 °C / Cooling with ice

2.2: pH 7

2.3: 16 h / 20 °C

3.1: Chiralcel OD-H / hexane; ethanol / 20 °C / Resolution of racemate

With potassium carbonate; pyridine hydrogenfluoride; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide;