N,6-dimethylpyridin-3-amine

Base Information

• Chemical Name: N,6-dimethylpyridin-3-amine
• CAS No.: 120739-89-1
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.17
• European Community (EC) Number: 852-382-0
• Mol file: 120739-89-1.mol

Synonyms:N,6-dimethylpyridin-3-amine;120739-89-1;3-Pyridinamine,N,6-dimethyl-(9CI);Methyl-(6-methyl-pyridin-3-yl)-amine;N,6-dimethyl-3-pyridinamine;SCHEMBL1746357;Methyl-(6-methylpyridin-3-yl)amine;MFCD23891645;AKOS018966842;SB75436;BS-14816;DB-143929;CS-0119514;D83365;EN300-2996603

Chemical Property of N,6-dimethylpyridin-3-amine

Chemical Property:

• Boiling Point: 211.2±20.0 °C(Predicted)
• PKA: 7.24±0.10(Predicted)
• PSA: 24.92000
• Density: 1.031±0.06 g/cm3(Predicted)
• LogP: 1.50470
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

95%+ ^*data from raw suppliers

Methyl-(6-methyl-pyridin-3-yl)-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=C(C=C1)NC

Technology Process of N,6-dimethylpyridin-3-amine

There total 1 articles about N,6-dimethylpyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Amino-2-methylpyridine (80287-53-2,3430-14-6) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → N,6-dimethylpyridin-3-amine (120739-89-1)

Guidance literature:

5-Amino-2-methylpyridine; formaldehyd; With sodium methylate; In methanol; at 50 ℃; for 16h;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 6h;

Reference yield:

C17H13ClN4O3 + N,6-dimethylpyridin-3-amine (120739-89-1) + trifluoroacetic acid (76-05-1) → 3-(4-(3-(2-chlorophenyl)ureido)-1H-pyrazol-1-yl)-N-methyl-N-(6-methylpyridin-3-yl)benzamide triflluoroacetate salt

Guidance literature:

C₁₇H₁₃ClN₄O₃; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 0.5h;

N,6-dimethylpyridin-3-amine; In dichloromethane;

trifluoroacetic acid; In methanol; water; acetonitrile;

DOI:10.1021/jm501256y

Reference yield:

N,6-dimethylpyridin-3-amine (120739-89-1) → methyl 2,3-dihydro-3-fluoro-1,5-dimethyl-2-oxo-1H-pyrrolo[3,2-b]pyridine-3-carboxylate

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 - 20 °C

2.1: sodium t-butanolate; zinc(II) chloride / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

3.1: ferrocene; lithium cyclopentadienide; tert-butylammonium hexafluorophosphate(V) / methanol; tetrahydrofuran / 0 °C / Molecular sieve; Inert atmosphere; Electrolysis

With ferrocene; lithium cyclopentadienide; tert-butylammonium hexafluorophosphate(V); triethylamine; zinc(II) chloride; sodium t-butanolate; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/anie.201701329

upstream raw materials:

5-Amino-2-methylpyridine

formaldehyd

Refernces

• 1、 -. "INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION". Page/Page column 51; 52. . Retrieved 2016/11/14.