1,1-dimethylethyl 3-[({3-[(9-chloro-4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]-5-[(3S)-tetrahydrofuran-3-yloxy]phenyl}carbonyl)amino]-1H-pyrazole-1-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl 3-[({3-[(9-chloro-4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]-5-[(3S)-tetrahydrofuran-3-yloxy]phenyl}carbonyl)amino]-1H-pyrazole-1-carboxylate
CAS No.:915771-50-5
Molecular Formula:C₂₉H₃₁ClN₄O₈
Molecular Weight:599.04
Hs Code.:

1,1-dimethylethyl 3-[({3-[(9-chloro-4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]-5-[(3S)-tetrahydrofuran-3-yloxy]phenyl}carbonyl)amino]-1H-pyrazole-1-carboxylate

Synonyms:1,1-dimethylethyl 3-[({3-[(9-chloro-4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]-5-[(3S)-tetrahydrofuran-3-yloxy]phenyl}carbonyl)amino]-1H-pyrazole-1-carboxylate

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Chemical Property of 1,1-dimethylethyl 3-[({3-[(9-chloro-4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]-5-[(3S)-tetrahydrofuran-3-yloxy]phenyl}carbonyl)amino]-1H-pyrazole-1-carboxylate

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Technology Process of 1,1-dimethylethyl 3-[({3-[(9-chloro-4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]-5-[(3S)-tetrahydrofuran-3-yloxy]phenyl}carbonyl)amino]-1H-pyrazole-1-carboxylate

There total 2 articles about 1,1-dimethylethyl 3-[({3-[(9-chloro-4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]-5-[(3S)-tetrahydrofuran-3-yloxy]phenyl}carbonyl)amino]-1H-pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 863504-84-1
3-aminopyrazole-1-carboxylic acid tert-butyl ester

: 915771-50-5
1,1-dimethylethyl 3-[({3-[(9-chloro-4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]-5-[(3S)-tetrahydrofuran-3-yloxy]phenyl}carbonyl)amino]-1H-pyrazole-1-carboxylate

Guidance literature:: 3-[(9-chloro-4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]-5-[(3S)-tetrahydrofuran-3-yloxy]benzoic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 20 ℃; for 0.5 - 0.666667h;

3-aminopyrazole-1-carboxylic acid tert-butyl ester; With pyridine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 915771-50-5
1,1-dimethylethyl 3-[({3-[(9-chloro-4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]-5-[(3S)-tetrahydrofuran-3-yloxy]phenyl}carbonyl)amino]-1H-pyrazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 2.08 h / 20 °C

2.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 - 0.67 h / 20 °C

2.2: 2 h / 20 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;