Imidazo[2,1-b]thiazole-6-carbaldehyde

Base Information

• Chemical Name: Imidazo[2,1-b]thiazole-6-carbaldehyde
• CAS No.: 120107-61-1
• Molecular Formula: C6H4 N2 O S
• Molecular Weight: 152.177
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID50406891
• Nikkaji Number: J3.224.933G
• Wikidata: Q82212026
• Mol file: 120107-61-1.mol

Synonyms:imidazo[2,1-b]thiazole-6-carbaldehyde;120107-61-1;imidazo[2,1-b][1,3]thiazole-6-carbaldehyde;Imidazo[2,1-b]thiazole-6-carboxaldehyde;SCHEMBL3400110;DTXSID50406891;VYBDPAAWKNKEKY-UHFFFAOYSA-N;VEA10761;MFCD07368517;AKOS006229130;AS-0179;CS-0078391;FT-0693412;D73917;imidazo[2,1-b]thiazole-6-carbaldehyde, AldrichCPR;W-205078;IMIDAZO[2,1-B]THIAZOLE-6-CARBOXALDEHYDEIMIDAZO

Chemical Property of Imidazo[2,1-b]thiazole-6-carbaldehyde

Chemical Property:

• Melting Point: 71 °C
• Refractive Index: 1.758
• Boiling Point: °Cat760mmHg
• PKA: 3.14±0.40(Predicted)
• Flash Point: °C
• PSA: 62.61000
• Density: 1.53g/cm³
• LogP: 1.20830
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 152.00443393
• Heavy Atom Count: 10
• Complexity: 153

Purity/Quality:

98%min ^*data from raw suppliers

Imidazo[2,1-b]thiazole-6-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC2=NC(=CN21)C=O

Technology Process of Imidazo[2,1-b]thiazole-6-carbaldehyde

There total 3 articles about Imidazo[2,1-b]thiazole-6-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

imidazo<2,1-b>thiazole-6-carboxylic acid tosylhydrazide (120107-62-2) → 6-formylimidazo<2,1-b>thiazole (120107-61-1)

Guidance literature:

With potassium carbonate; In ethylene glycol; at 130 - 140 ℃; for 0.0833333h;

DOI:10.1016/0223-5234(88)90214-0

Reference yield:

6-ethoxycarbonyl-imidazo<2,1-b>thiazole (64951-04-8) → 6-formylimidazo<2,1-b>thiazole (120107-61-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / hydrazine hydrate / H₂O / 5 h / Heating

2: 89 percent / pyridine / 4 h / Ambient temperature

3: 46 percent / K₂CO₃ / ethane-1,2-diol / 0.08 h / 130 - 140 °C

With pyridine; potassium carbonate; hydrazine hydrate; In water; ethylene glycol;

DOI:10.1016/0223-5234(88)90214-0

Reference yield:

imidazo<2,1-b>thiazole-6-carboxylic acid hydrazide (119448-36-1) → 6-formylimidazo<2,1-b>thiazole (120107-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / pyridine / 4 h / Ambient temperature

2: 46 percent / K₂CO₃ / ethane-1,2-diol / 0.08 h / 130 - 140 °C

With pyridine; potassium carbonate; In ethylene glycol;

DOI:10.1016/0223-5234(88)90214-0

upstream raw materials:

imidazo<2,1-b>thiazole-6-carboxylic acid tosylhydrazide

6-ethoxycarbonyl-imidazo<2,1-b>thiazole

imidazo<2,1-b>thiazole-6-carboxylic acid hydrazide

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