64951-04-8

Usage

Uses

Used in Medicinal Chemistry:
ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE is used as a building block for the synthesis of bioactive compounds, contributing to the development of new pharmaceuticals.
Used in Drug Development:
ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE is utilized as a starting material in the creation of novel drugs, thanks to its unique chemical structure and potential for medicinal applications.
Used in Agrochemicals:
ETHYL IMIDAZO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE is also used as a starting material for the synthesis of agrochemicals, indicating its broad applicability in chemical industries beyond healthcare.

InChI:InChI=1/C8H8N2O2S/c1-2-12-7(11)6-5-10-3-4-13-8(10)9-6/h3-5H,2H2,1H3

Upstream product

• 96-50-4 2-thiazolylamine 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 120107-62-2 imidazo<2,1-b>thiazole-6-carboxylic acid tosylhydrazide 
• 120107-61-1 6-formylimidazo<2,1-b>thiazole 
• 53572-98-8 imidazo[2,1-b]thiazole-6-carboxylic acid 

Relevant academic research and scientific papers

A new multifunctional sensor for sequential recognizing of Zn2+ and PPi in acetonitrile solution and detection of In3+ in DMF solution

A simple multifunctional sensor, X, was designed and synthesized based on 8-hydroxy-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-9-carbaldehyde and imidazo[2,1-b]thiazole, which could sequentially identify Zn2+ and PPi in acetonitrile buffer solution through the presence or absence of fluorescent signals and could detect In3+ in DMF buffer solution with obvious fluorescence enhancement. The detection limit for Zn2+, PPi and In3+ were calculated to be 4.58 × 10?8 M, 1.07 × 10?8 M and 2.9 × 10?8 M, respectively. Moreover, X could quantitatively detect Zn2+, PPi and In3+ in real water samples with the satisfactory recovery rate (90.1 %–97.6 %) and RSD (0.86 %–3.09 %). In addition, the complexation ratio between X and metal ions (Zn2+ and In3+) was 1:1, which was proved by mass spectrometry titration. The binding mode and sensing mechanism of X to metal ions (Zn2+ and In3+) were verified by Gaussian calculation based on B3LYP/6-31 G(d) and B3LYP/LanL2DZ basis set.

A selective "turn-on" sensor for recognizing In3+ and Zn2+ in respective systems based on imidazo[2,1-: B] thiazole

A new simple and easily synthesized multitarget sensor, (E)-N′-(4-(diethylamino)-2-hydroxybenzylidene)imidazo[2,1-b]thiazole-6-carbohydrazide (X), was designed and synthesized using imidazo[2,1-b]thiazole-6-carboxylic acid and 4-(diethylamino)-2-hydroxybenzaldehyde. X could be used as a sensor to detect In3+ in DMF-H2O buffer solution and detect Zn2+ in EtOH-H2O buffer solution through fluorescence enhancement with detection limits of 1.02 × 10-9 M and 5.5 × 10-9 M, respectively. X exhibited an efficient "off-on-off" fluorescence behavior by cyclic addition of metal ions (In3+ and Zn2+) and EDTA. The stoichiometry between X and metal ions (In3+ and Zn2+) was 1:1. The binding mode and sensing mechanism of X with metal ions (In3+ and Zn2+) was verified by theoretical calculations using Gaussian 09 based on B3LYP/6-31G(d) and B3LYP/LANL2DZ basis, respectively. Moreover, X could be applied as a potential sensor for the quantitative detection of In3+ and Zn2+ with a satisfactory recovery and relative standard deviation (RSD) in real water samples.

A simple sensor based on imidazo[2,1-b]thiazole for recognition and differentiation of Al3+, F? and PPi

Based on imidazo[2,1-b]thiazole and 2,3-dihydroxybenzaldehyde, a simple sensor, (E)-N'-(2,3-dihydroxybenzylidene)imidazo[2,1-b]thiazole-6-carbohydrazide (X), was designed and synthesized and its fluorescence responses to various ions were explored in DMF/

A new “off-on-off” sensor for sequential detection of Al3+ and Cu2+ with excellent sensitivity and selectivity based on different sensing mechanisms

A new simple Schiff base, (E)-N'-(2-hydroxybenzylidene)imidazo[2,1-b]thiazole-6-carbohydrazide (X), was designed and synthesized based on salicylaldehyde and imidazo[2, 1-b]thiazole. X could be used as a sensor to identify Al3+ through a significant fluorescence enhancement because of CHEF and inhibition of PET process and then to detect Cu2+ through a highly efficient quenching behavior due to the paramagnetic quenching. The sensor showed a high selectivity for Al3+ and Cu2+ in methanol solution at pH = 5 and was not disturbed by other competing metal ions. Furthermore, based on the equation 3σ/slope, the detection limits of sensor for Al3+ and Cu2+ were calculated to be 3.1 × 10?10 M and 9.8 × 10-11 M, respectively. Additionally, the association constants of X[Al3+] and X[Cu2+] were also determined to be 2.3 × 104 M-1 and 6.1 × 104 M-1 on basis of Benesi-Hildebrand equation. In addition, the titration experiment of fluorescence and mass spectrometry showed that sensor was combined with Al3+ or Cu2+ both in 1:1 ratio. Moreover, the optimized structure and energy calculations of X, X[Al3+] and X[Cu2+] were obtained by Gaussian software based on the basis set of B3LYP/6?31 G(d) and B3LYP/LANL2DZ. And, the sensor successfully detected Al3+ and Cu2+ in the real water sample with a satisfactory recovery (91.4 % - 107.1 %) and RSD values (0.66 % - 1.91 %).

A simple fluorescent schiff base for sequential detection of Zn2+ and PPi based on imidazo[2,1-b]thiazole

A simple fluorescent schiff base, X, based on imidazo[2,1-b]thiazole-6-carboxylic acid and 3-ethoxy-2-hydroxybenzaldehyde, was designed and synthesized for detection of Zn2+ and PPi. X showed excellent sensitivity and selectivity toward Zn

A dual functional fluorescent sensor for the detection of Al3+ and Zn2+ in different solvents

(E)-N′-((2-Hydroxynaphthalen-1-yl)methylene)imidazo[2,1-b]thiazole-6-carbohydrazide (X), a new fluorescent sensor, was designed and synthesized based on imidazo[2,1-b]thiazole and 2-hydroxy-1-naphthaldehyde, which could be used to detect Al3+ in methanol buffer solution and detect Zn2+ in ethanol buffer solution with detection limits of 1.45 × 10-7 M and 1.29 × 10-8 M, respectively. X showed high sensitivity and selectivity towards Al3+ and Zn2+ in the presence of other metal ions. The fluorescence intensity of X was reversible even after six cycles with the sequentially alternative addition of metal ions (Al3+ and Zn2+) and PPi, showing an efficient "off-on-off" fluorescence behavior. The complexation ratio of X to Al3+ and Zn2+ was 1:1, which was proved by mass spectrometry and the B-H equation. The binding mode and sensing mechanism of X with metal ions (Al3+ and Zn2+) were verified by DFT/TDDFT calculations using Gaussian 09 based on the B3LYP/6-31G(d) basis set.

Imidazole [2, 1-b] thiazole derivative as well as preparation method and application thereof

The invention belongs to the field of chemical pharmaceuticals, and particularly relates to an imidazole [2, 1-b] thiazole derivative as well as a preparation method and an application thereof. The structure of the imidazole [2, 1-b] thiazole derivative i

Discovery of imidazo[2,1- b ]thiazole HCV NS4B inhibitors exhibiting synergistic effect with other direct-acting antiviral agents

The design, synthesis, and SAR studies of novel inhibitors of HCV NS4B based on the imidazo[2,1-b]thiazole scaffold were described. Optimization of potency with respect to genotype 1b resulted in the discovery of two potent leads 26f (EC50 = 16

SUBSTITUTED HETEROARYL FUSED DERIVATIVES AS PI3K INHIBITORS

The present invention provides fused derivatives of Formula (I) that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PBKs including, for example, inflammatory disorders, immune- based disorders, cancer, and other diseases.

Modulators of S1P and Methods of Making And Using

The invention is directed to Compounds of Formula I: as well as methods of making and using the compounds.