benzoic acid 4-tert-butoxycarbonylamino-3,3-difluoro-2,5-dihydroxypentyl ester

Base Information

Chemical Name:benzoic acid 4-tert-butoxycarbonylamino-3,3-difluoro-2,5-dihydroxypentyl ester
CAS No.:799257-30-0
Molecular Formula:C₁₇H₂₃F₂NO₆
Molecular Weight:375.37
Hs Code.:

Synonyms:benzoic acid 4-tert-butoxycarbonylamino-3,3-difluoro-2,5-dihydroxypentyl ester

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Chemical Property of benzoic acid 4-tert-butoxycarbonylamino-3,3-difluoro-2,5-dihydroxypentyl ester

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Technology Process of benzoic acid 4-tert-butoxycarbonylamino-3,3-difluoro-2,5-dihydroxypentyl ester

There total 7 articles about benzoic acid 4-tert-butoxycarbonylamino-3,3-difluoro-2,5-dihydroxypentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: benzoic acid 4-tert-butoxycarbonylamino-3,3-difluoro-5-hydroxytetrahydrofuran-2-ylmethyl ester

: 799257-30-0
benzoic acid 4-tert-butoxycarbonylamino-3,3-difluoro-2,5-dihydroxypentyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.333333h;
DOI:10.1021/ol048423j

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 799257-30-0
benzoic acid 4-tert-butoxycarbonylamino-3,3-difluoro-2,5-dihydroxypentyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / CH₂Cl₂ / 10 h / 20 °C

2: 45 percent / NMNO; OsO₄ / acetone; H₂O / 48 h / 20 °C

3: 84 percent / pyridine / CH₂Cl₂ / 2 h / -78 °C

4: aq. AcOH / 3 h / 50 °C

5: 1.70 g / NaIO₄ / acetone; H₂O / 3 h / 20 °C

6: 90 percent / NaBH₄ / methanol / 0.33 h / 0 °C

With pyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; bis-(2-chloro-ethyl)-methyl-amine oxide; acetic acid; In methanol; dichloromethane; water; acetone;
DOI:10.1021/ol048423j

Reference yield:

: 98-88-4
benzoyl chloride

: 799257-30-0
benzoic acid 4-tert-butoxycarbonylamino-3,3-difluoro-2,5-dihydroxypentyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / pyridine / CH₂Cl₂ / 2 h / -78 °C

2: aq. AcOH / 3 h / 50 °C

3: 1.70 g / NaIO₄ / acetone; H₂O / 3 h / 20 °C

4: 90 percent / NaBH₄ / methanol / 0.33 h / 0 °C

With pyridine; sodium tetrahydroborate; sodium periodate; acetic acid; In methanol; dichloromethane; water; acetone;
DOI:10.1021/ol048423j