Technology Process of 1-{3-[(p-anisyloxy)methyl]-2,3-dideoxy-5-O-phosphoryl-β-D-erythro-pentofuranosyl}thymine
There total 7 articles about 1-{3-[(p-anisyloxy)methyl]-2,3-dideoxy-5-O-phosphoryl-β-D-erythro-pentofuranosyl}thymine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-{3-[(p-anisyloxy)methyl]-2,3-dideoxy-β-D-erythro-pentofuranosyl}thymine;
With
trichlorophosphate;
In
various solvent(s);
at 0 - 20 ℃;
for 5.5h;
With
ammonium hydroxide;
In
various solvent(s);
DOI:10.1021/jm021108n
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: trimethylsilyl chloride; pyridine / Heating
2.1: trimethylsilyl triflate / 1,2-dichloro-ethane / 5 h / 20 °C
3.1: 592 mg / NH3 / methanol / 15 h / 20 °C
4.1: DMAP / acetonitrile / 1.5 h / 0 °C
5.1: 3.98 g / 2,2'-azobis(2-methyl-propionitrile); tri-n-butyltinhydride / toluene / 1 h / 95 - 100 °C
6.1: 85 percent / H2 / Pd/C / methanol / 5 h / atmospheric pressure
7.1: POCl3 / various solvent(s) / 5.5 h / 0 - 20 °C
7.2: 52 percent / aq. NH3 / various solvent(s)
With
pyridine; dmap; chloro-trimethyl-silane; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; ammonia; hydrogen; tri-n-butyl-tin hydride; trichlorophosphate;
palladium on activated charcoal;
In
methanol; 1,2-dichloro-ethane; toluene; acetonitrile;
2.1: Vorbrueggen-type coupling;
DOI:10.1021/jm021108n
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trimethylsilyl triflate / 1,2-dichloro-ethane / 5 h / 20 °C
2.1: 592 mg / NH3 / methanol / 15 h / 20 °C
3.1: DMAP / acetonitrile / 1.5 h / 0 °C
4.1: 3.98 g / 2,2'-azobis(2-methyl-propionitrile); tri-n-butyltinhydride / toluene / 1 h / 95 - 100 °C
5.1: 85 percent / H2 / Pd/C / methanol / 5 h / atmospheric pressure
6.1: POCl3 / various solvent(s) / 5.5 h / 0 - 20 °C
6.2: 52 percent / aq. NH3 / various solvent(s)
With
dmap; 2,2'-azobis(isobutyronitrile); trimethylsilyl trifluoromethanesulfonate; ammonia; hydrogen; tri-n-butyl-tin hydride; trichlorophosphate;
palladium on activated charcoal;
In
methanol; 1,2-dichloro-ethane; toluene; acetonitrile;
1.1: Vorbrueggen-type coupling;
DOI:10.1021/jm021108n
![1-{3-[(p-anisyloxy)methyl]-2,3-dideoxy-β-D-erythro-pentofuranosyl}thymine](/Databaselist/images/loading.webp)
