(E)-1-(4-methoxyphenyl)-4,4-dimethyl-7-[(triisopropylsilyl)oxy]hept-2-en-1-one

Base Information

• Chemical Name: (E)-1-(4-methoxyphenyl)-4,4-dimethyl-7-[(triisopropylsilyl)oxy]hept-2-en-1-one
• CAS No.: 1309113-40-3
• Molecular Formula: C₂₅H₄₂O₃Si
• Molecular Weight: 418.692
• Mol file: 1309113-40-3.mol

Synonyms:(E)-1-(4-methoxyphenyl)-4,4-dimethyl-7-[(triisopropylsilyl)oxy]hept-2-en-1-one

Chemical Property of (E)-1-(4-methoxyphenyl)-4,4-dimethyl-7-[(triisopropylsilyl)oxy]hept-2-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(4-methoxyphenyl)-4,4-dimethyl-7-[(triisopropylsilyl)oxy]hept-2-en-1-one

There total 1 articles about (E)-1-(4-methoxyphenyl)-4,4-dimethyl-7-[(triisopropylsilyl)oxy]hept-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1-(4-methoxyphenyl)ethanone (100-06-1) + 2,2-dimethyl-5-((triisopropylsilyl)oxy)pentanal (184174-46-7) → (E)-1-(4-methoxyphenyl)-4,4-dimethyl-7-[(triisopropylsilyl)oxy]hept-2-en-1-one (1309113-40-3)

Guidance literature:

With methanol; sodium hydride; In mineral oil; for 15h; Inert atmosphere; Reflux;

DOI:10.1002/anie.201006880

Reference yield: 99.0%

(E)-1-(4-methoxyphenyl)-4,4-dimethyl-7-[(triisopropylsilyl)oxy]hept-2-en-1-one (1309113-40-3) → (E)-1-(4-methoxyphenyl)-4,4-dimethyl-7-[(triisopropylsilyl)oxy]hept-2-en-1-ol (1309113-42-5)

Guidance literature:

With sodium tetrahydroborate; cerium(III) chloride; In methanol; at 0 ℃; for 0.25h; Inert atmosphere;

DOI:10.1002/anie.201006880

Reference yield:

(E)-1-(4-methoxyphenyl)-4,4-dimethyl-7-[(triisopropylsilyl)oxy]hept-2-en-1-one (1309113-40-3) → (E)-1-(4-methoxyphenyl)-4,4-dimethyl-7-[(triisopropylsilyl)oxy]hept-1-en-3-yl acetate (1309113-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; cerium(III) chloride / methanol / 0.25 h / 0 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0 °C / Inert atmosphere

With sodium tetrahydroborate; cerium(III) chloride; triethylamine; In methanol; dichloromethane;

DOI:10.1002/anie.201006880

upstream raw materials:

1-(4-methoxyphenyl)ethanone

2,2-dimethyl-5-((triisopropylsilyl)oxy)pentanal

Downstream raw materials:

(E)-1-(4-methoxyphenyl)-4,4-dimethyl-7-[(triisopropylsilyl)oxy]hept-2-en-1-ol

(E)-1-(4-methoxyphenyl)-4,4-dimethyl-7-[(triisopropylsilyl)oxy]hept-1-en-3-yl acetate

(E)-7-hydroxy-1-(4-methoxyphenyl)-4,4-dimethylhept-1-en-3-yl acetate

(E)-1-(4-methoxyphenyl)-4,4-dimethyl-7-oxohept-1-en-3-yl acetate