2-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-isoindole-1,3-dione

Base Information

Chemical Name:2-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-isoindole-1,3-dione
CAS No.:145290-53-5
Molecular Formula:C₂₆H₁₈N₆O₂S
Molecular Weight:478.534
Hs Code.:

Synonyms:2-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-isoindole-1,3-dione

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Chemical Property of 2-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-isoindole-1,3-dione

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Technology Process of 2-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-isoindole-1,3-dione

There total 4 articles about 2-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1074-82-4
potassium phtalimide

: 145290-52-4
Methanesulfonic acid 2-[6-(2-azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl ester

: 145290-53-5
2-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-isoindole-1,3-dione

Guidance literature:: In N,N-dimethyl-formamide; at 50 ℃;
DOI:10.1021/ja00051a062

Reference yield:

: 145290-51-3
2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethanol

: 145290-53-5
2-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

2: 84 percent / dimethylformamide / 8 h / 50 °C

With triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00155a010

Reference yield:

: 145290-49-9
Acetic acid 2-[2-amino-6-(2-azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl ester

: 145290-53-5
2-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: isoamyl nitrite / dimethylformamide / 80 °C

2: 93 percent / K₂CO₃, methanol / 0.25 h / Ambient temperature

3: 99 percent / Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

4: 84 percent / dimethylformamide / 8 h / 50 °C

With methanol; potassium carbonate; triethylamine; isopentyl nitrite; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00155a010