tert-butyl-2-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexylamino)-2-oxoethylcarbamate

Base Information

Chemical Name:tert-butyl-2-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexylamino)-2-oxoethylcarbamate
CAS No.:1188931-98-7
Molecular Formula:C₄₃H₈₀N₂O₅Si₂
Molecular Weight:761.29
Hs Code.:

tert-butyl-2-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexylamino)-2-oxoethylcarbamate

Synonyms:tert-butyl-2-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexylamino)-2-oxoethylcarbamate

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Chemical Property of tert-butyl-2-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexylamino)-2-oxoethylcarbamate

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Technology Process of tert-butyl-2-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexylamino)-2-oxoethylcarbamate

There total 6 articles about tert-butyl-2-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexylamino)-2-oxoethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 4530-20-5
BOC-glycine

: 1188931-91-0
(R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexan-1-amine

: 1188931-98-7
tert-butyl-2-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexylamino)-2-oxoethylcarbamate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: (S)-5-((1R,3aR,4S,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)-1-ethoxyhex-1-ene

: 1188931-98-7
tert-butyl-2-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexylamino)-2-oxoethylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium chlorochromate / dichloromethane / 3 h / Molecular sieve

1.2: 24 h / 20 °C

1.3: 3 h / 20 °C / Molecular sieve

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere; Cooling with ice

2.2: 3.08 h / -78 - 20 °C / Inert atmosphere

2.3: Saturated solution

3.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C / Inert atmosphere

4.1: O-benzylhydoxylamine hydrochloride; sodium acetate / toluene / 0.5 h / Reflux

4.2: 0 - 20 °C / Inert atmosphere

5.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

With dmap; O-benzylhydoxylamine hydrochloride; sodium acetate; sodium hexamethyldisilazane; diisobutylaluminium hydride; dicyclohexyl-carbodiimide; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 957214-13-0
(5S)-5-((1R,3R,7E,17β)-1,3-bis[tert-butyl(dimethyl)silyloxy]-9,10-secoestra-5,7-dien-17-yl)hexanal

: 1188931-98-7
tert-butyl-2-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexylamino)-2-oxoethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-benzylhydoxylamine hydrochloride; sodium acetate / toluene / 0.5 h / Reflux

1.2: 0 - 20 °C / Inert atmosphere

2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

With dmap; O-benzylhydoxylamine hydrochloride; sodium acetate; dicyclohexyl-carbodiimide; In dichloromethane; toluene;