(3S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1'-(5-(1-hydroxyethyl)pyridin-2-yl)-[1,4'-bipiperidin]-2-one

Base Information

Chemical Name:(3S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1'-(5-(1-hydroxyethyl)pyridin-2-yl)-[1,4'-bipiperidin]-2-one
CAS No.:1351166-75-0
Molecular Formula:C₂₄H₃₀F₂N₄O₄S
Molecular Weight:508.589
Hs Code.:

Synonyms:(3S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1'-(5-(1-hydroxyethyl)pyridin-2-yl)-[1,4'-bipiperidin]-2-one

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Chemical Property of (3S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1'-(5-(1-hydroxyethyl)pyridin-2-yl)-[1,4'-bipiperidin]-2-one

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Technology Process of (3S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1'-(5-(1-hydroxyethyl)pyridin-2-yl)-[1,4'-bipiperidin]-2-one

There total 11 articles about (3S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1'-(5-(1-hydroxyethyl)pyridin-2-yl)-[1,4'-bipiperidin]-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.6%

: 1351168-30-3
(S)-1'-(5-acetylpyridin-2-yl)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one

: 1351166-75-0
(3S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1'-(5-(1-hydroxyethyl)pyridin-2-yl)-[1,4'-bipiperidin]-2-one

Guidance literature:: With methanol; sodium tetrahydroborate; at 20 ℃; for 1h;

Reference yield:

: 2640-58-6
Nα-benzyloxycarbonyl-L-ornithine

: 1351166-75-0
(3S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1'-(5-(1-hydroxyethyl)pyridin-2-yl)-[1,4'-bipiperidin]-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: water; tetrahydrofuran / 1 h

1.2: 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol

4.1: sodium carbonate / N,N-dimethyl-formamide / 130 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 100 °C

7.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 851120-61-1
(S)-tert-butyl 3-(benzyloxycarbonylamino)-2-oxo-1,4'-bipiperidin-1'-carboxylate

: 1351166-75-0
(3S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-1'-(5-(1-hydroxyethyl)pyridin-2-yl)-[1,4'-bipiperidin]-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / methanol

2: sodium carbonate / N,N-dimethyl-formamide / 130 °C

3: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 20 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 100 °C

5: sodium tetrahydroborate; methanol / 1 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;