Technology Process of 2,4,5-trifluorobenzenesulfinic acid
There total 1 articles about 2,4,5-trifluorobenzenesulfinic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,4,5-trifluorobenzene-1-sulfonyl chloride;
With
sodium hydroxide; sodium sulfite;
In
water;
pH=14;
With
sulfuric acid;
In
water;
pH=~ 1;
Cooling with ice;
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
2: sodium carbonate / N,N-dimethyl-formamide / 130 °C
3: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 20 °C
4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 120 °C
5: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 8 h / 95 °C / Inert atmosphere
With
hydrogenchloride; sodium carbonate; N-ethyl-N,N-diisopropylamine;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
