6-((4-Methoxy-benzyl)-{6-[(4-methoxy-benzyl)-propionyl-amino]-hexanoyl}-amino)-hexanoic acid (4-methoxy-benzyl)-{5-[(4-methoxy-benzyl)-(5-propylcarbamoyl-pentyl)-carbamoyl]-pentyl}-amide

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Chemical Name:6-((4-Methoxy-benzyl)-{6-[(4-methoxy-benzyl)-propionyl-amino]-hexanoyl}-amino)-hexanoic acid (4-methoxy-benzyl)-{5-[(4-methoxy-benzyl)-(5-propylcarbamoyl-pentyl)-carbamoyl]-pentyl}-amide
CAS No.:200713-77-5
Molecular Formula:C₆₂H₈₉N₅O₉
Molecular Weight:1048.42
Hs Code.:

6-((4-Methoxy-benzyl)-{6-[(4-methoxy-benzyl)-propionyl-amino]-hexanoyl}-amino)-hexanoic acid (4-methoxy-benzyl)-{5-[(4-methoxy-benzyl)-(5-propylcarbamoyl-pentyl)-carbamoyl]-pentyl}-amide

Synonyms:6-((4-Methoxy-benzyl)-{6-[(4-methoxy-benzyl)-propionyl-amino]-hexanoyl}-amino)-hexanoic acid (4-methoxy-benzyl)-{5-[(4-methoxy-benzyl)-(5-propylcarbamoyl-pentyl)-carbamoyl]-pentyl}-amide

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Chemical Property of 6-((4-Methoxy-benzyl)-{6-[(4-methoxy-benzyl)-propionyl-amino]-hexanoyl}-amino)-hexanoic acid (4-methoxy-benzyl)-{5-[(4-methoxy-benzyl)-(5-propylcarbamoyl-pentyl)-carbamoyl]-pentyl}-amide

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Technology Process of 6-((4-Methoxy-benzyl)-{6-[(4-methoxy-benzyl)-propionyl-amino]-hexanoyl}-amino)-hexanoic acid (4-methoxy-benzyl)-{5-[(4-methoxy-benzyl)-(5-propylcarbamoyl-pentyl)-carbamoyl]-pentyl}-amide

There total 13 articles about 6-((4-Methoxy-benzyl)-{6-[(4-methoxy-benzyl)-propionyl-amino]-hexanoyl}-amino)-hexanoic acid (4-methoxy-benzyl)-{5-[(4-methoxy-benzyl)-(5-propylcarbamoyl-pentyl)-carbamoyl]-pentyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 107-10-8,42939-71-9
propylamine

: 200713-76-4
6-[(4-Methoxy-benzyl)-(6-{(4-methoxy-benzyl)-[6-((4-methoxy-benzyl)-{6-[(4-methoxy-benzyl)-propionyl-amino]-hexanoyl}-amino)-hexanoyl]-amino}-hexanoyl)-amino]-hexanoic acid ethyl ester

: 200713-77-5
6-((4-Methoxy-benzyl)-{6-[(4-methoxy-benzyl)-propionyl-amino]-hexanoyl}-amino)-hexanoic acid (4-methoxy-benzyl)-{5-[(4-methoxy-benzyl)-(5-propylcarbamoyl-pentyl)-carbamoyl]-pentyl}-amide

Guidance literature:: With potassium cyanide; In methanol; for 60h; Heating;

Reference yield:

: 371-34-6
ethyl 6-aminohexanoate

: 200713-77-5
6-((4-Methoxy-benzyl)-{6-[(4-methoxy-benzyl)-propionyl-amino]-hexanoyl}-amino)-hexanoic acid (4-methoxy-benzyl)-{5-[(4-methoxy-benzyl)-(5-propylcarbamoyl-pentyl)-carbamoyl]-pentyl}-amide

Guidance literature:: Multi-step reaction with 10 steps

1: p-CH₃-C₆H₄-SO₃H*H₂O / ethanol; toluene / 18 h / Heating

2: NaBH₄ / methanol / 40 - 50 °C

3: 71 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 98 percent / aq. NaOH / 120 °C

5: 75 percent / DCC, 1-HOBt / CH₂Cl₂ / 1.) r.t., 40 min, 2.) 5 deg C,18 h

6: 77 percent / TFA / CH₂Cl₂ / 5 h / Ambient temperature

7: 87 percent / DCC, 1-HOBt / CH₂Cl₂ / 1.) r.t., 1 h, 2.) r.t., 18 h

8: 94 percent / TFA / 4 h / 0 °C

9: 84 percent / Et₃N / CH₂Cl₂ / 0 - 5 °C

10: 95 percent / KCN / methanol / 60 h / Heating

With potassium cyanide; sodium hydroxide; sodium tetrahydroborate; benzotriazol-1-ol; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 6-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-hexanoic acid ethyl ester

: 200713-77-5
6-((4-Methoxy-benzyl)-{6-[(4-methoxy-benzyl)-propionyl-amino]-hexanoyl}-amino)-hexanoic acid (4-methoxy-benzyl)-{5-[(4-methoxy-benzyl)-(5-propylcarbamoyl-pentyl)-carbamoyl]-pentyl}-amide

Guidance literature:: Multi-step reaction with 9 steps

1: NaBH₄ / methanol / 40 - 50 °C

2: 71 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

3: 98 percent / aq. NaOH / 120 °C

4: 75 percent / DCC, 1-HOBt / CH₂Cl₂ / 1.) r.t., 40 min, 2.) 5 deg C,18 h

5: 77 percent / TFA / CH₂Cl₂ / 5 h / Ambient temperature

6: 87 percent / DCC, 1-HOBt / CH₂Cl₂ / 1.) r.t., 1 h, 2.) r.t., 18 h

7: 94 percent / TFA / 4 h / 0 °C

8: 84 percent / Et₃N / CH₂Cl₂ / 0 - 5 °C

9: 95 percent / KCN / methanol / 60 h / Heating

With potassium cyanide; sodium hydroxide; sodium tetrahydroborate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; dichloromethane;