1-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-(4-methoxy-phenyl)-propynone

Base Information

• Chemical Name: 1-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-(4-methoxy-phenyl)-propynone
• CAS No.: 642089-50-7
• Molecular Formula: C₂₂H₂₆O₃Si
• Molecular Weight: 366.532
• Mol file: 642089-50-7.mol

Synonyms:1-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-(4-methoxy-phenyl)-propynone

Chemical Property of 1-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-(4-methoxy-phenyl)-propynone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-(4-methoxy-phenyl)-propynone

There total 4 articles about 1-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-(4-methoxy-phenyl)-propynone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-(4-methoxy-phenyl)-prop-2-yn-1-ol → 1-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-(4-methoxy-phenyl)-propynone (642089-50-7)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 25 ℃;

DOI:10.1055/s-2003-42049

Reference yield:

2-methyl-benzyl alcohol (89-95-2) → 1-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-(4-methoxy-phenyl)-propynone (642089-50-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 95 percent / imidazole / CH₂Cl₂ / 25 °C

2.1: n-BuLi / tetrahydrofuran / -78 °C

2.2: tetrahydrofuran

3.1: MnO₂ / CH₂Cl₂ / 25 °C

With 1H-imidazole; manganese(IV) oxide; n-butyllithium; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-2003-42049

Reference yield:

2-((tert-butyldimethylsilyl)oxy)benzaldehyde (116585-12-7) → 1-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-(4-methoxy-phenyl)-propynone (642089-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran

2.1: MnO₂ / CH₂Cl₂ / 25 °C

With manganese(IV) oxide; n-butyllithium; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-2003-42049

upstream raw materials:

2-methyl-benzyl alcohol

2-((tert-butyldimethylsilyl)oxy)benzaldehyde

tert-butyldimethylsilyl chloride