(+/-)-Vesamicol hydrochloride

Base Information

Chemical Name:(+/-)-Vesamicol hydrochloride
CAS No.:120447-62-3
Molecular Formula:C₁₇H₂₅NO*ClH
Molecular Weight:295.853
Hs Code.:
UNII:N29SQS860M
Wikidata:Q27284418
ChEMBL ID:CHEMBL1333097
Mol file:120447-62-3.mol

Synonyms:(+/-)-Vesamicol hydrochloride;AH-5183 hydrochloride;Vesamicol hydrochloride, (+/-)-;L-(-)-Vesamicol hydrochloride;N29SQS860M;Cyclohexanol, 2-(4-phenyl-1-piperidinyl)-, hydrochloride, trans-(+/-)-;( inverted exclamation markA)-Vesamicol (hydrochloride);Cyclohexanol, 2-(4-phenyl-1-piperidinyl)-, hydrochloride, trans-;Cyclohexanol, 2-(4-phenyl-1-piperidinyl)-, hydrochloride (1:1), (1R,2R)-rel-;SMR000057879;SR-01000597931;NSC-759580;UNII-N29SQS860M;MLS000079837;MLS000758211;MLS001163935;MLS001423983;CHEMBL1333097;HY-B1813A;AKOS024458596;CCG-100776;NC00026;NSC 759580;NCGC00180933-01;CS-0020773;SR-01000597931-1;SR-01000597931-6;Q27284418;(+/-)-trans-2-(4-Phenylpiperidinyl)cyclohexanol hydrochloride;(1R,2R)-2-(4-phenylpiperidin-1-yl)cyclohexanol hydrochloride;(1R,2R)-Cyclohexanol, 2-(4-phenyl-1-piperidinyl)-, hydrochloride;rel-(1R,2R)-2-(4-Phenylpiperidin-1-yl)cyclohexan-1-olhydrochloride;rel-(1R,2R)-2-(4-Phenylpiperidin-1-yl)cyclohexan-1-ol hydrochloride;1166453-59-3

Suppliers and Price of (+/-)-Vesamicol hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
rel-VesamicolHydrochloride
100mg
$ 150.00

ApexBio Technology
(±)-Vesamicolhydrochloride
250mg
$ 156.00

American Custom Chemicals Corporation
(+/-)-VESAMICOL HYDROCHLORIDE 95.00%
5MG
$ 499.80

Total 8 raw suppliers

Chemical Property of (+/-)-Vesamicol hydrochloride

Chemical Property:

Vapor Pressure:6.73E-07mmHg at 25°C
Refractive Index: ">
Boiling Point:393.5°Cat760mmHg
Flash Point:97°C
PSA：23.47000
Density:g/cm³
LogP:3.90940
Solubility.:aqueous buffers below pH 8: 1 mM
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:295.1702921
Heavy Atom Count:20
Complexity:266

Purity/Quality:

98%min ^*data from raw suppliers

rel-VesamicolHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(C(C1)N2CCC(CC2)C3=CC=CC=C3)O.Cl
Isomeric SMILES:C1CC[C@H]([C@@H](C1)N2CCC(CC2)C3=CC=CC=C3)O.Cl
Uses (+/-)-VesamicolmiddotHCl (AH-5183) is a blocker of acetylcholine transfer into nerve terminal vesicles.

Technology Process of (+/-)-Vesamicol hydrochloride

There total 3 articles about (+/-)-Vesamicol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: (+/-)-2-(4-phenylpiperidino)cyclohexanone

: 120447-62-3,23965-53-9
(+/-)-cis-vesamicol hydrochloride

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethanol; for 3h; under 2280 Torr; Ambient temperature;
DOI:10.1021/jm00126a013

Reference yield:

: 1056477-06-5,822-85-5
2-bromocyclohexanone

: 120447-62-3,23965-53-9
(+/-)-cis-vesamicol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / CHCl₃ / 168 h

2: 35 percent / H₂ / PtO₂ / ethanol / 3 h / 2280 Torr / Ambient temperature

With hydrogen; platinum(IV) oxide; In ethanol; chloroform;
DOI:10.1021/jm00126a013

Reference yield:

: 771-99-3
4-phenylpiperidine

: 120447-62-3,23965-53-9
(+/-)-cis-vesamicol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / CHCl₃ / 168 h

2: 35 percent / H₂ / PtO₂ / ethanol / 3 h / 2280 Torr / Ambient temperature

With hydrogen; platinum(IV) oxide; In ethanol; chloroform;
DOI:10.1021/jm00126a013