3-benzyl-2-(naphthalen-2-yl)-2,3-dihydroquinazolin-4(1H)-one

Base Information

• Chemical Name: 3-benzyl-2-(naphthalen-2-yl)-2,3-dihydroquinazolin-4(1H)-one
• CAS No.: 1352001-22-9
• Molecular Formula: C₂₅H₂₀N₂O
• Molecular Weight: 364.447
• Mol file: 1352001-22-9.mol

Synonyms:3-benzyl-2-(naphthalen-2-yl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property of 3-benzyl-2-(naphthalen-2-yl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzyl-2-(naphthalen-2-yl)-2,3-dihydroquinazolin-4(1H)-one

There total 2 articles about 3-benzyl-2-(naphthalen-2-yl)-2,3-dihydroquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

isatoic anhydride (118-48-9) + β-naphthaldehyde (66-99-9) + benzylamine (100-46-9) → 3-benzyl-2-(naphthalen-2-yl)-2,3-dihydroquinazolin-4(1H)-one (1352001-22-9)

Guidance literature:

With 1-methylimidazolium nitrate; at 80 ℃; for 1h;

DOI:10.1002/jhet.721

Reference yield: 72.0%

carbon monoxide (201230-82-2) + 2-iodophenylamine (615-43-0) + N-(naphthalen-2-ylmethylene)-1-phenylmethanamine (141120-50-5,24091-01-8) → 3-benzyl-2-(naphthalen-2-yl)-2,3-dihydroquinazolin-4(1H)-one (1352001-22-9)

Guidance literature:

With potassium phosphate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In toluene; at 120 ℃; for 12h; under 760.051 Torr; Inert atmosphere; Schlenk technique;

DOI:10.1002/asia.202000359

upstream raw materials:

isatoic anhydride

β-naphthaldehyde

benzylamine

carbon monoxide