2,2,2-trifluoroethyl 3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenylmethanesulfonate

Base Information

• Chemical Name: 2,2,2-trifluoroethyl 3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenylmethanesulfonate
• CAS No.: 1227752-00-2
• Molecular Formula: C₂₁H₂₄F₃N₅O₄S
• Molecular Weight: 499.514
• Mol file: 1227752-00-2.mol

Synonyms:2,2,2-trifluoroethyl 3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenylmethanesulfonate

Chemical Property of 2,2,2-trifluoroethyl 3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenylmethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trifluoroethyl 3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenylmethanesulfonate

There total 1 articles about 2,2,2-trifluoroethyl 3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenylmethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2,2,2-trifluoroethyl (3-aminophenyl)methanesulfonate (1227751-99-6) + 6-(cyclohexylmethoxy)-2-fluoro-9H-purine (444723-30-2) → 2,2,2-trifluoroethyl 3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenylmethanesulfonate (1227752-00-2)

Guidance literature:

With trifluoroacetic acid; In 2,2,2-trifluoroethanol; for 24h; Reflux;

DOI:10.1039/b922717b

Reference yield: 93.0%

4-(2-AMINOETHYL)MORPHOLINE (2038-03-1) + 2,2,2-trifluoroethyl 3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenylmethanesulfonate (1227752-00-2) → 1-[3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenyl]-N-(2-morpholin-4-ylethyl)methanesulfonamide (1227752-07-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 160 ℃; for 0.25h; Microwave irradiation;

DOI:10.1039/b922717b

Reference yield: 92.0%

2,2,2-trifluoroethyl 3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenylmethanesulfonate (1227752-00-2) + 1-amino-3-(dimethylamino)propane (109-55-7) → 1-[3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenyl]-N-(3-dimethylaminopropyl)methanesulfonamide (1227752-05-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 160 ℃; for 0.25h; Microwave irradiation;

DOI:10.1039/b922717b

upstream raw materials:

2,2,2-trifluoroethyl (3-aminophenyl)methanesulfonate

6-(cyclohexylmethoxy)-2-fluoro-9H-purine

Downstream raw materials:

1-(3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenylmethanesulfonyl)pyrrolidine

1-(3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenylmethanesulfonyl)piperidine

4-(3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenylmethanesulfonyl)morpholine

1-(3-(6-cyclohexylmethoxy-9H-purin-2-ylamino)phenylmethanesulfonyl)piperazine