tert-butyl (3-(1-(3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-3-carbonyl)piperidin-4-yl)benzyl)carbamate

Base Information

Chemical Name:tert-butyl (3-(1-(3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-3-carbonyl)piperidin-4-yl)benzyl)carbamate
CAS No.:1411992-62-5
Molecular Formula:C₃₆H₄₅BN₂O₅
Molecular Weight:596.575
Hs Code.:

Synonyms:tert-butyl (3-(1-(3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-3-carbonyl)piperidin-4-yl)benzyl)carbamate

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Chemical Property of tert-butyl (3-(1-(3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-3-carbonyl)piperidin-4-yl)benzyl)carbamate

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Technology Process of tert-butyl (3-(1-(3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-3-carbonyl)piperidin-4-yl)benzyl)carbamate

There total 9 articles about tert-butyl (3-(1-(3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-3-carbonyl)piperidin-4-yl)benzyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1411992-59-0
3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1, 1′-biphenyl]-3-carboxylic acid

: 725228-49-9
tert-butyl 3-(piperidin-4-yl)benzylcarbamate

: 1411992-62-5
tert-butyl (3-(1-(3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-3-carbonyl)piperidin-4-yl)benzyl)carbamate

Guidance literature:: 3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1, 1′-biphenyl]-3-carboxylic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.25h;

tert-butyl 3-(piperidin-4-yl)benzylcarbamate; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 854237-06-2
3′-bromo-[1,1′-biphenyl]-3-carboxylic acid

: 1411992-62-5
tert-butyl (3-(1-(3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-3-carbonyl)piperidin-4-yl)benzyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride

1.2: 4 h / 65 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 4 h / 80 °C / Inert atmosphere

3.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0.25 h / 0 °C

4.2: 4 h / 20 °C

With dmap; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1411992-56-7
methyl 3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-3-carboxylate

: 1411992-62-5
tert-butyl (3-(1-(3′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-3-carbonyl)piperidin-4-yl)benzyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 0.25 h / 0 °C

2.2: 4 h / 20 °C

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane;