Cyclohexanecarboxaldehyde, 4-methoxy- (9CI)

Base Information

• Chemical Name: Cyclohexanecarboxaldehyde, 4-methoxy- (9CI)
• CAS No.: 120552-57-0
• Molecular Formula: C₈H₁₄O₂
• Molecular Weight: 142.198
• Mol file: 120552-57-0.mol

Synonyms:4-Methoxycyclohexanecarboxaldehyde

Chemical Property of Cyclohexanecarboxaldehyde, 4-methoxy- (9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

4-Methoxy-cyclohexanecarbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanecarboxaldehyde, 4-methoxy- (9CI)

There total 13 articles about Cyclohexanecarboxaldehyde, 4-methoxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

((1R,4R)-4-methoxycyclohexyl)methanol (101869-74-3) → (1r,4r)-4-methoxycyclohexane-1-carbaldehyde (120552-57-0)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; water; at 20 ℃; for 4h; Cooling with ice;

Reference yield: 76.0%

cis-methyl 4-methoxycyclohexane-1-carboxylate (73873-60-6) → (1s,4s)-4-methoxycyclohexanecarbaldehyde (120552-57-0)

Guidance literature:

cis-methyl 4-methoxycyclohexane-1-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 4h;

Reference yield: 67.0%

(4-methoxy-cyclohexyl)-methanol (101869-74-3) → 4-methoxycyclohexane-1-carbaldehyde (120552-57-0)

Guidance literature:

With HMTAB; silica gel; In water; at 20 ℃; for 0.333333h;

upstream raw materials:

(4-methoxy-cyclohexyl)-methanol

4-methoxycyclohexanone

(methoxymethyl)triphenylphosphonium chloride

4,4-ethylenedioxycyclohexan-1-ol

Refernces

• 1、 -. "NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF". Paragraph 00152. . Retrieved 2020/12/01.
• 2、 -. "ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF". . . Retrieved 2016/04/20.