(S)-O-[(2,2-DIMETHYL-1,3-DIOXOLAN-4-YL)METHYL]-HYDROXYAMINE HYDROHLORIDE

Base Information

• Chemical Name: (S)-O-[(2,2-DIMETHYL-1,3-DIOXOLAN-4-YL)METHYL]-HYDROXYAMINE HYDROHLORIDE
• CAS No.: 120564-14-9
• Molecular Formula: C6H13 N O3
• Molecular Weight: 147.174
• Mol file: 120564-14-9.mol

Synonyms:Hydroxylamine,O-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-, (S)-;(S)-O-[(2,2-Dimethyl-[1,3]dioxolan-4-yl)methyl]hydroxylamine;[((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)methoxy]amine

Chemical Property of (S)-O-[(2,2-DIMETHYL-1,3-DIOXOLAN-4-YL)METHYL]-HYDROXYAMINE HYDROHLORIDE

Chemical Property:

• Boiling Point: 220.2±15.0 °C(Predicted)
• PKA: 4.07±0.70(Predicted)
• PSA: 53.71000
• Density: 1.048±0.06 g/cm3(Predicted)
• LogP: 1.53050

Purity/Quality:

98%min ^*data from raw suppliers

(S)-O-((2,2-Dimethyl-1,3-dioxolan-4-yl)methyl)hydroxylamine 95.00 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-O-[(2,2-DIMETHYL-1,3-DIOXOLAN-4-YL)METHYL]-HYDROXYAMINE HYDROHLORIDE

There total 10 articles about (S)-O-[(2,2-DIMETHYL-1,3-DIOXOLAN-4-YL)METHYL]-HYDROXYAMINE HYDROHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

(R)-2-(2,2-Dimethyl-[1,3]dioxolan-4-ylmethoxy)-isoindole-1,3-dione (131068-34-3) → (4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxyamine (120564-14-9,114778-50-6)

Guidance literature:

With methylhydrazine; In dichloromethane; at 3 - 20 ℃; for 2h;

Reference yield: 98.3%

(S)-N-<(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy>phthalimide (131068-35-4) → (S)-O-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)hydroxylamine (120564-14-9)

Guidance literature:

With methylhydrazine; In dichloromethane; at 3 - 20 ℃; for 2h;

Reference yield: 91.0%

→ (S)-2,2-Dimethyl-l,3-dioxolan-4-ylmethoxyamine + (S)-O-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)hydroxylamine (120564-14-9)

Guidance literature:

upstream raw materials:

(S)-N-<(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy>phthalimide

1,2-O-isopropylidene-D-glycerol

(S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol

(R)-2-(2,2-Dimethyl-[1,3]dioxolan-4-ylmethoxy)-isoindole-1,3-dione

Downstream raw materials:

C₂₁H₂₄BrN₅O₄

PD0325901

N-[(S)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide

5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)pyrazolo[1,5-a]pyrimidine-3-carboxamide