131068-35-4Relevant academic research and scientific papers
TRICYCLIC COMPOUND HAVING SULFINYL OR SULFONYL
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Paragraph 0401; 0402, (2018/05/24)
It is intended to provide a compound that exhibits a strong antibacterial spectrum against various bacteria including gram-negative bacteria, or a pharmaceutical composition having an antibacterial activity against carbapenem-resistant bacteria. The present invention provides a compound represented by formula (I): wherein -W- is -S(=O)- or -S(=O)2-, -T- is -CR4AR4B- or -CR5AR5B-CR6AR6B-, R4A, R4B, R5A, R5B, R6A and R6B are each independently a hydrogen atom or the like, R1 is substituted or unsubstituted heterocyclyl or the like, R2A and R2B are each independently a hydrogen atom or the like, or R2A and R2B are taken together to form substituted or unsubstituted methylidene or the like, and R3 is a hydrogen atom or the like, R11 is carboxy or the like, R7A and R7b are each independently a hydrogen atom or the like, its ester form or a pharmaceutically acceptable salt thereof, or a hydrate thereof.
PHARMACEUTICAL COMPOSITION CONTAINING TRICYCLIC COMPOUND HAVING SULFINYL OR SULFONYL
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Paragraph 0256, (2018/08/02)
PROBLEM TO BE SOLVED: To provide a pharmaceutical composition that has antibacterial activity against carbapenem-resistant bacteria. SOLUTION: A pharmaceutical composition contains a compound represented by formula (I), its ester body or their pharmaceutically acceptable salts, or their hydrates (W is S(=O) or S(=O)2; T is CR4AR4B or CR5AR5B-CR6AR6B; R4A, R4B, R5A, R5B, R6A and R6B independently represent halogen, hydroxy, carbonyl, alkyl, cycloalkyl, aryl or the like; R1 is a carbocycle or heterocycle; R2A and R2B independently represent H, amino, hydroxy and the like, or R2A and R2B together form methylidene, hydroxyimino and the like; R3 is H, methoxy or the like). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
N-(4-substituted phenyl)-anthranilic acid hydroxamate esters
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Page/Page column 13, (2010/02/06)
The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions, and methods of use thereof.
Synthesis and Antiviral Activity of 9-Alkoxypurines. 2. 9-(2,3-Dihydroxypropoxy)-, 9-(3,4-Dihydroxybutoxy)-, and 9-(1,4-Dihydroxybut-2-oxy)purines
Bailey, Stuart,Harnden, Michael R.,Jarvest, Richard L.,Parkin, Ann,Boyd, Malcolm R.
, p. 57 - 65 (2007/10/02)
Reaction of alkenoxyamines (3, 5) or (R,S)-, (R)-, and (S)-hydroxy-protected derivatives of hydroxyalkoxyamines (20a,b, 37a-c) with 4,6-dichloro-2,5-diformamidopyrimidine (4) and cyclization of the resultant 6-- and 6-(alkoxyamino)pyrimid
Purine compounds, process for their preparation, intermediates and pharmaceutical compositions
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, (2008/06/13)
The (S)-isomer of a compound of formula (I), optionally in admixture with up to 45% of the mixture by weight of the corresponding (R)-isomer: wherein the OH groups in the chain are optionally in the form of O-acyl, phosphate, cyclic acetal or cyclic carbonate derivatives thereof; having antiviral activity, a process for preparation and use as pharmaceuticals.
