Technology Process of N-(4-(4-(2-(2-fluorophenyl)propan-2-yl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide
There total 10 articles about N-(4-(4-(2-(2-fluorophenyl)propan-2-yl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 12h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tetrahydrofuran / 1 h / -70 °C / Inert atmosphere
2.1: trifluoroacetic acid; sodium azide / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
3.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / 20 h / 125 °C / Inert atmosphere
5.1: 4-hydroxy-benzoic acid; hydrogen bromide; acetic acid / 48 h / 20 °C / Inert atmosphere
5.2: 2 h
6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
With
sodium azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen bromide; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 4-hydroxy-benzoic acid;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: trifluoroacetic acid; sodium azide / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
2.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C
3.1: N-ethyl-N,N-diisopropylamine / 20 h / 125 °C / Inert atmosphere
4.1: 4-hydroxy-benzoic acid; hydrogen bromide; acetic acid / 48 h / 20 °C / Inert atmosphere
4.2: 2 h
5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere
With
sodium azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen bromide; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 4-hydroxy-benzoic acid;
palladium 10% on activated carbon;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
