methyl 2-methoxy-3-methyl-5-[4-(2-methyl-2H-tetrazol-5-yl)but-1-ynyl]benzoate

Base Information

Chemical Name:methyl 2-methoxy-3-methyl-5-[4-(2-methyl-2H-tetrazol-5-yl)but-1-ynyl]benzoate
CAS No.:954371-31-4
Molecular Formula:C₁₆H₁₈N₄O₃
Molecular Weight:314.344
Hs Code.:

Synonyms:methyl 2-methoxy-3-methyl-5-[4-(2-methyl-2H-tetrazol-5-yl)but-1-ynyl]benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-methoxy-3-methyl-5-[4-(2-methyl-2H-tetrazol-5-yl)but-1-ynyl]benzoate

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Technology Process of methyl 2-methoxy-3-methyl-5-[4-(2-methyl-2H-tetrazol-5-yl)but-1-ynyl]benzoate

There total 1 articles about methyl 2-methoxy-3-methyl-5-[4-(2-methyl-2H-tetrazol-5-yl)but-1-ynyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 954371-25-6
5-but-3-ynyl-2-methyl-2H-tetrazole

: 6082-99-1
5-iodo-2-methoxy-3-methylbenzoic acid methyl ester

: 954371-31-4
methyl 2-methoxy-3-methyl-5-[4-(2-methyl-2H-tetrazol-5-yl)but-1-ynyl]benzoate

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 14.5h;
DOI:10.1021/jm070382k

Reference yield:

: 954371-31-4
methyl 2-methoxy-3-methyl-5-[4-(2-methyl-2H-tetrazol-5-yl)but-1-ynyl]benzoate

: 6082-99-1
5-iodo-2-methoxy-3-methylbenzoic acid methyl ester

: methyl 2-methoxy-5-[1-(4-methoxy-3-methyl-5-methoxycarbonyl-phenyl)-4-(2-methyl-2H-tetrazol-5-yl)-but-1-enyl]-3-methylbenzoate

Guidance literature:: methyl 2-methoxy-3-methyl-5-[4-(2-methyl-2H-tetrazol-5-yl)but-1-ynyl]benzoate; With tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 0 - 20 ℃;

5-iodo-2-methoxy-3-methylbenzoic acid methyl ester; With copper(l) iodide; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 60 ℃; for 17h; Further stages.;
DOI:10.1021/jm070382k

Reference yield:

: 954371-31-4
methyl 2-methoxy-3-methyl-5-[4-(2-methyl-2H-tetrazol-5-yl)but-1-ynyl]benzoate

: 6952-59-6
3-cyanobromobenzene

: (Z)-5-[1-(3-cyanophenyl)-4-(2-methyl-2H-tetrazol-5-yl)but-1-enyl]-2-methoxy-3-methylbenzoic acid methyl ester

Guidance literature:: methyl 2-methoxy-3-methyl-5-[4-(2-methyl-2H-tetrazol-5-yl)but-1-ynyl]benzoate; With tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 0 - 20 ℃;

3-cyanobromobenzene; With copper(l) iodide; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 60 ℃; for 13.5h; Further stages.;
DOI:10.1021/jm070382k