4-Pyridinepropanal(9CI)

Base Information

• Chemical Name: 4-Pyridinepropanal(9CI)
• CAS No.: 120690-80-4
• Molecular Formula: C8H9 N O
• Molecular Weight: 135.166
• Mol file: 120690-80-4.mol

Synonyms:3-(4-Pyridyl)propionaldehyde;3-(4-pyridyl)propanal; 3-(Pyridin-4-yl)propanal;3-(Pyridin-4-yl)propionaldehyde

Chemical Property of 4-Pyridinepropanal(9CI)

Chemical Property:

• Boiling Point: 234.9±15.0 °C(Predicted)
• PKA: 5.81±0.10(Predicted)
• PSA: 29.96000
• Density: 1.045±0.06 g/cm3(Predicted)
• LogP: 1.21310

Purity/Quality:

97% ^*data from raw suppliers

3-Pyridin-4-ylpropanal ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridinepropanal(9CI)

There total 12 articles about 4-Pyridinepropanal(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-(3-Hydroxypropyl)pyridine (2629-72-3) → 3-(pyridin-4-yl)propionaldehyde (120690-80-4)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/jm049932u

Reference yield: 75.0%

4-vinylpyridine (100-43-6,329041-72-7) + 2,2-diethoxy acetic acid (20461-86-3) → 3-(pyridin-4-yl)propionaldehyde (120690-80-4)

Guidance literature:

4-vinylpyridine; 2,2-diethoxy acetic acid; With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h; Inert atmosphere; Flow reactor; Irradiation;

With hydrogenchloride; In water; N,N-dimethyl-formamide; for 12h;

DOI:10.1021/jacs.7b05082

Reference yield: 64.0%

4-vinylpyridine (100-43-6,329041-72-7) + carbon monoxide (201230-82-2) → 4-Ethylpyridine (536-75-4,151103-55-8) + 3-(pyridin-4-yl)propionaldehyde (120690-80-4)

Guidance literature:

With Rh(acac)(CO)2; 3,3',5,5'-tetra(2,4-difluorophenyl)-2,2',6,6'-tetra((di-1-pyrrolylphosphino)oxy)-1,1'-biphenyl; hydrogen; In toluene; at 120 ℃; for 2h; under 3800.26 Torr; regioselective reaction; Autoclave;

DOI:10.1002/chem.201201396

upstream raw materials:

4-vinylpyridine

carbon monoxide

4-(3-Hydroxypropyl)pyridine

Dess-Martin periodane

Downstream raw materials:

4-{2-[4-(4-methylbenzenesulfonyl)-4,5-dihydrooxazol-5-yl]ethyl}pyridine

4-(but-3-en-1-yl)pyridine

C₁₈H₂₂N₄S*ClH

4-(4-pyridinyl)butan-1-ol