2-(4-tert-butylphenyl)-5,7-dimethyl-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitrile

Base Information

Chemical Name:2-(4-tert-butylphenyl)-5,7-dimethyl-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitrile
CAS No.:1207614-72-9
Molecular Formula:C₂₀H₂₀N₄O₃
Molecular Weight:364.404
Hs Code.:

Synonyms:2-(4-tert-butylphenyl)-5,7-dimethyl-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitrile

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Chemical Property of 2-(4-tert-butylphenyl)-5,7-dimethyl-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitrile

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Technology Process of 2-(4-tert-butylphenyl)-5,7-dimethyl-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitrile

There total 3 articles about 2-(4-tert-butylphenyl)-5,7-dimethyl-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 769-42-6
1,3-dimethylbarbituric acid

: 149550-23-2
2-(4-(tert-butyl) benzylidene) malononitrile

: 1207614-72-9
2-(4-tert-butylphenyl)-5,7-dimethyl-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitrile

Guidance literature:: With bromine; sodium ethanolate; In ethanol; at 20 ℃; for 3h;
DOI:10.1016/j.tetlet.2009.11.065

Reference yield: 63.0%

: 769-42-6
1,3-dimethylbarbituric acid

: 939-97-9
4-tert-Butylbenzaldehyde

: 109-77-3
malononitrile

: 1207614-72-9
2-(4-tert-butylphenyl)-5,7-dimethyl-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitrile

Guidance literature:: 4-tert-Butylbenzaldehyde; malononitrile; With sodium acetate; sodium bromide; In methanol; for 0.5h;

1,3-dimethylbarbituric acid; In methanol; at 10 ℃; for 0.533333h; Electrochemical reaction;
DOI:10.1016/j.tet.2012.12.029

Reference yield:

: 939-97-9
4-tert-Butylbenzaldehyde

: 1207614-72-9
2-(4-tert-butylphenyl)-5,7-dimethyl-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate / ethanol / 0.5 h / Reflux

2: bromine; sodium ethanolate / ethanol / 3 h

With bromine; sodium ethanolate; sodium acetate; In ethanol;
DOI:10.1016/j.tet.2012.12.029