149550-23-2

Upstream product

• 3395-82-2 4-t-butylbenzaldehyde dimethyl acetal 
• 109-77-3 malononitrile 
• 877-65-6 p-tert-butylbenzyl alcohol 
• 939-97-9 4-tert-Butylbenzaldehyde 

Downstream Products

• 1239897-27-8 C₂₇H₂₉N₃O₄ 
• 1422263-76-0 2-(4-tert-butylphenyl)-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitrile 
• 1417627-99-6 2-(1-(4-(tert-butyl)phenyl)-2-((3,5-dimethylphenyl)(methyl)amino)ethyl)malononitrile 
• 1417627-81-6 3-(4-(tert-butyl)phenyl)-1,7-dimethyl-2,3-dihydroquinoline-4,4(1H)-dicarbonitrile 
• 1417627-95-2 2-(1-(4-(tert-butyl)phenyl)-2-((4-(tert-butyl)phenyl)(methyl)amino)ethyl)malononitrile 

Relevant academic research and scientific papers

Visible-Light Photoredox-Catalyzed α-Regioselective Conjugate Addition of Allyl Groups to Activated Alkenes

The α-regioselective conjugate addition of allyl groups to activated alkenes is a poorly explored area of research. Herein, we report an α-adduct and (E)-isomer selective conjugate addition of allylsilanes to activated alkenes by visible-light photoredox catalysis. The reaction involves allylic radicals that can be generated from allylsilanes through a photoinduced single-electron transfer mechanism. (Figure presented.).

Synthesis, Structure, and Ligand-Centered Catalytic Properties of MII Coordination Polymers (M=ZnII, CdII, HgII) with Open Pyridyl N-Oxide Sites

Four MII (M=ZnII, CdII, HgII) coordination polymers were designed and synthesized based on two pyridine N-oxide bridging ligands: 3,5-bis(4-pyridyl)pyridine N-oxide and 2,6-bis(3-pyridyl)pyridine N-oxide. The re

An efficient and recyclable acid-base bifunctional core-shell nano-catalyst for the one-pot deacetalization-Knoevenagel tandem reaction

A novel magnetic nanoparticle supported acid-base bifunctional catalyst was synthesized by anchoring [3-(2-aminoethyl)aminopropyl]triethoxysilane and sulfonic acid successively onto the surface of silica-coated Fe3O4 nanoparticles. The as-prepared nanoparticle catalyst was used as a quasi-homogeneous and recyclable catalyst for the one-pot deacetalization-Knoevenagel tandem reaction of benzaldehyde dimethylacetals and malononitrile. It showed high catalytic activity because the reaction proceeded smoothly and afforded benzylidenemalononitriles in excellent yields. Besides, it showed synergistic effect and facilitated the mass transfer process during the tandem reaction because the two catalytic moieties were connected together on the same MNP. Moreover, the catalyst can be readily recovered under an external magnetic field and reused without any significant loss of the catalytic activity after six runs.

A Stable Amino-Functionalized Interpenetrated Metal-Organic Framework Exhibiting Gas Selectivity and Pore-Size-Dependent Catalytic Performance

An amino-functionalized doubly interpenetrated microporous zinc metal-organic framework (UPC-30) has been solvothermally synthesized. UPC-30 can be stable at 190 °C and confirmed by powder X-ray diffraction. Gas adsorption measurements indicate that UPC-3

Synthesis of Fe3O4@P4VP@ZIF-8 core-shell microspheres and their application in a Knoevenagel condensation reaction

In this work, a core-shell magnetic composite Fe3O4@P4VP@ZIF-8 microspheres were successfully designed and synthesized. A polymerization approach on the surface of pre-made Fe3O4 microspheres was employed for th

Kinetically Controllable Pd-Catalyzed Decarboxylation Enabled [5 + 2] and [3 + 2] Cycloaddition toward Carbocycles Featuring Quaternary Carbons

A decarboxylative protocol has been developed toward a range of carbocycles. The key success is based on the use of a batch of newly designed cyclic carbonates as substrates that can provide carbon-carbon zwitterion intermediate under palladium catalysis.

Nickel?alkyne?functionalized metal?organic frameworks: An efficient and reusable catalyst

Electron-donating groups in the robust MOF motif are able to provide an excellent catalytic platform, therefore obtaining site-isolated metal sites. In this study, the terminal alkyne is firstly introduced into UiO-66-type metal-organic frameworks (UiO-66-alkyne). Herein, to further study the application potential of this material, a covalently bonded nickel catalyst based on the alkynyl-tagged UiO-66-alkyne has been prepared and afforded us unprecedented highly dispersed and highly efficient catalytic active species. Meanwhile, this nickel-contained catalyst method for joining metals provided an alternative pathway regarding catalyst designing. With UiO-66-alkyne-Ni, the heterogeneous transformation of homogeneous catalysts is realized. Using benzaldehyde and malononitrile as starting materials, we were able to catalyze the Knoevenagel condensation within 45 min under room temperature with yield (> 99 %). Moreover, the recovery rate of the UiO-66-alkyne-Ni also outperformed previous MOFs in both small-scale and gram-level reactions, which shows UiO-66-alkyne-Ni is a potential contributor to the subsequent industrialization.

Controllable one-pot synthesis for scaffold diversity: Via visible-light photoredox-catalyzed Giese reaction and further transformation

This study presents a controllable one-pot synthesis for constructing valuable scaffolds (alcohols, 2,3-dihydrofurans, α-cyano-γ-butyrolactones, and γ-butyrolactones) via a visible-light photoredox-catalyzed Giese reaction and further transformation. This

Preparation of O-Protected Cyanohydrins by Aerobic Oxidation of α-Substituted Malononitriles in the Presence of Diarylphosphine Oxides

A mild, reagent-cyanide-free, and efficient synthesis of O-phosphinoyl-protected cyanohydrins from readily available α-substituted malononitriles was realized using diarylphosphine oxides in the presence of O2. Mechanistic studies indicated that in addition to the initial aerobic oxidation of the malononitrile derivative notable features of this process include the formation of a tetrahedral intermediate and a subsequent intramolecular rearrangement. The phosphinoyl-protecting group can be removed by alcoholysis or by reduction with DIBAL-H.

Efficient and Reusable Pb(II) Metal–Organic Framework for Knoevenagel Condensation

A microporous lead–organic framework {[Pb4(μ8-MTB)2(H2O)4]·5DMF·H2O}n (MTB = methanetetrabenzoate, DMF = N,N′-dimethylformamide) was synthesized and studied as a catalyst in Knoevenagel condensation reactions. The framework is built from tetranuclear [Pb4(μ3-COO)(μ2-COO)6(COO)(H2O)4] clusters and exhibits a 3D structure, with repeated 1D jar-like cavities with sizes about 14.98 × 7.88 and 14.98 × 13.17??2 and BET specific surface area of 980?m2?g?1. To obtain open framework with unsaturated Pb(II) sites needed for catalysis, the thermal activation of the solvent exchanged sample was performed (DMF was exchanged by EtOH). The activated compound was tested in Knoevenagel condensation of bulky aldehydes and active methylene compounds at different temperatures. Excellent catalytic conversion and selectivity in condensation of small-sized aldehydes with malononitrile was observed, which indicates that the opened Pb(II) sites play a significant role in the heterogeneous catalytic process. Leaching test confirmed the stability of the catalyst in catalytic reactions. Moreover, the compound displayed good recyclability after several reuses without significant decrease in the original catalytic activity. Graphical Abstract: Novel Pb(II) metal–organic framework was tested in Knoevenagel condensation. The catalyst showed excellent catalytic conversion, selectivity and recyclability. Aldehydes with lower kinetic diameter demonstrated high conversions and yields. Catalyst is less efficient for condensation of larger aromatic aldehydes. [Figure not available: see fulltext.].