Technology Process of C30H31FN8O2
There total 10 articles about C30H31FN8O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; HATU;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 80 °C
2.1: hydrogen / palladium 10% on activated carbon / toluene; methanol
3.1: sodium nitrite; sulfuric acid / water / 0.5 h / 0 °C
3.2: 0 - 20 °C
4.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol; tetrahydrofuran / 32 h / 20 °C
5.1: trifluoroacetic acid / 0.5 h / 20 °C
6.1: sodium tris(acetoxy)borohydride / methanol / 16 h / 20 °C
7.1: lithium hydroxide / 16 h / 50 °C
8.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C
With
potassium phosphate; copper(ll) sulfate pentahydrate; sulfuric acid; hydrogen; sodium tris(acetoxy)borohydride; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; sodium nitrite;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 80 °C
2.1: hydrogen / palladium 10% on activated carbon / toluene; methanol
3.1: sodium nitrite; sulfuric acid / water / 0.5 h / 0 °C
3.2: 0 - 20 °C
4.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol; tetrahydrofuran / 32 h / 20 °C
5.1: trifluoroacetic acid / 0.5 h / 20 °C
6.1: sodium tris(acetoxy)borohydride / methanol / 16 h / 20 °C
7.1: lithium hydroxide / 16 h / 50 °C
8.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C
With
potassium phosphate; copper(ll) sulfate pentahydrate; sulfuric acid; hydrogen; sodium tris(acetoxy)borohydride; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; sodium nitrite;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;