[(2S,4aS,7R,8aR)-3-(cyclohex-1-en-1-ylmethyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2-yl](phenyl)methanone

Base Information

Chemical Name:[(2S,4aS,7R,8aR)-3-(cyclohex-1-en-1-ylmethyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2-yl](phenyl)methanone
CAS No.:914359-66-3
Molecular Formula:C₂₅H₃₅NO₂
Molecular Weight:381.558
Hs Code.:

Synonyms:[(2S,4aS,7R,8aR)-3-(cyclohex-1-en-1-ylmethyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2-yl](phenyl)methanone

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Chemical Property of [(2S,4aS,7R,8aR)-3-(cyclohex-1-en-1-ylmethyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2-yl](phenyl)methanone

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Technology Process of [(2S,4aS,7R,8aR)-3-(cyclohex-1-en-1-ylmethyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2-yl](phenyl)methanone

There total 3 articles about [(2S,4aS,7R,8aR)-3-(cyclohex-1-en-1-ylmethyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2-yl](phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 37677-17-1
1-bromomethylcyclohexene

: 503004-87-3
(2S,4aS,7R,8aR)-phenyl-[4,4,7-trimethyloctahydrobenzo[e][1,3]oxazin-2-yl] ketone

: 914359-66-3
[(2S,4aS,7R,8aR)-3-(cyclohex-1-en-1-ylmethyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2-yl](phenyl)methanone

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 - 90 ℃; for 60h;
DOI:10.1021/jo061547k

Reference yield:

: 18448-47-0
methyl cyclohex-1-ene-1-carboxylate

: 914359-66-3
[(2S,4aS,7R,8aR)-3-(cyclohex-1-en-1-ylmethyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2-yl](phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄

2: CBr₄; PPh₃ / CH₂Cl₂

3: 81 percent / K₂CO₃ / acetonitrile / 60 h / 80 - 90 °C

With lithium aluminium tetrahydride; carbon tetrabromide; potassium carbonate; triphenylphosphine; In dichloromethane; acetonitrile;
DOI:10.1021/jo061547k

Reference yield:

: 4845-04-9
1-cyclohexene-1-methanol

: 914359-66-3
[(2S,4aS,7R,8aR)-3-(cyclohex-1-en-1-ylmethyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2-yl](phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: CBr₄; PPh₃ / CH₂Cl₂

2: 81 percent / K₂CO₃ / acetonitrile / 60 h / 80 - 90 °C

With carbon tetrabromide; potassium carbonate; triphenylphosphine; In dichloromethane; acetonitrile;
DOI:10.1021/jo061547k