(1R,2S,1'S,6'aS,9'R,10'aR,11'aS)-1'-phenyl-2-phenylselenenyl-6',6',9'-trimethyl-decahydro-3'H,7'H-spiro[cyclohexane-1,3'-[1,4]oxazino[3,4-b][1,3]benzoxazine]

Base Information

Chemical Name:(1R,2S,1'S,6'aS,9'R,10'aR,11'aS)-1'-phenyl-2-phenylselenenyl-6',6',9'-trimethyl-decahydro-3'H,7'H-spiro[cyclohexane-1,3'-[1,4]oxazino[3,4-b][1,3]benzoxazine]
CAS No.:914359-76-5
Molecular Formula:C₃₁H₄₁NO₂Se
Molecular Weight:538.632
Hs Code.:

Synonyms:(1R,2S,1'S,6'aS,9'R,10'aR,11'aS)-1'-phenyl-2-phenylselenenyl-6',6',9'-trimethyl-decahydro-3'H,7'H-spiro[cyclohexane-1,3'-[1,4]oxazino[3,4-b][1,3]benzoxazine]

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Chemical Property of (1R,2S,1'S,6'aS,9'R,10'aR,11'aS)-1'-phenyl-2-phenylselenenyl-6',6',9'-trimethyl-decahydro-3'H,7'H-spiro[cyclohexane-1,3'-[1,4]oxazino[3,4-b][1,3]benzoxazine]

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Technology Process of (1R,2S,1'S,6'aS,9'R,10'aR,11'aS)-1'-phenyl-2-phenylselenenyl-6',6',9'-trimethyl-decahydro-3'H,7'H-spiro[cyclohexane-1,3'-[1,4]oxazino[3,4-b][1,3]benzoxazine]

There total 5 articles about (1R,2S,1'S,6'aS,9'R,10'aR,11'aS)-1'-phenyl-2-phenylselenenyl-6',6',9'-trimethyl-decahydro-3'H,7'H-spiro[cyclohexane-1,3'-[1,4]oxazino[3,4-b][1,3]benzoxazine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 914359-70-9
(S)-[(2S,4aS,7R,8aR)-3-(cyclohex-1-en-1-ylmethyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2-yl](phenyl)methanol

: 5707-04-0
Phenylselenyl chloride

: 914359-83-4
(1S,2R,1'S,6'aS,9'R,10'aR,11'aS)-1'-phenyl-2-phenylselenenyl-6',6',9'-trimethyl-decahydro-3'H,7'H-spiro[cyclohexane-1,3'-[1,4]oxazino[3,4-b][1,3]benzoxazine]

: 914359-76-5
(1R,2S,1'S,6'aS,9'R,10'aR,11'aS)-1'-phenyl-2-phenylselenenyl-6',6',9'-trimethyl-decahydro-3'H,7'H-spiro[cyclohexane-1,3'-[1,4]oxazino[3,4-b][1,3]benzoxazine]

Guidance literature:: Phenylselenyl chloride; With tin(IV) chloride; In dichloromethane; at -78 ℃; for 0.333333h;

(S)-[(2S,4aS,7R,8aR)-3-(cyclohex-1-en-1-ylmethyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2-yl](phenyl)methanol; In dichloromethane; at -78 ℃; for 2h;
DOI:10.1021/jo061547k

Reference yield:

: 914359-66-3
[(2S,4aS,7R,8aR)-3-(cyclohex-1-en-1-ylmethyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2-yl](phenyl)methanone

: 914359-76-5
(1R,2S,1'S,6'aS,9'R,10'aR,11'aS)-1'-phenyl-2-phenylselenenyl-6',6',9'-trimethyl-decahydro-3'H,7'H-spiro[cyclohexane-1,3'-[1,4]oxazino[3,4-b][1,3]benzoxazine]

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / NaBH₄ / ethanol / 5 h / -10 - 0 °C

2.1: SnCl₄ / CH₂Cl₂ / 0.33 h / -78 °C

2.2: CH₂Cl₂ / 2 h / -78 °C

With sodium tetrahydroborate; tin(IV) chloride; In ethanol; dichloromethane;
DOI:10.1021/jo061547k

Reference yield:

: 18448-47-0
methyl cyclohex-1-ene-1-carboxylate

: 914359-76-5
(1R,2S,1'S,6'aS,9'R,10'aR,11'aS)-1'-phenyl-2-phenylselenenyl-6',6',9'-trimethyl-decahydro-3'H,7'H-spiro[cyclohexane-1,3'-[1,4]oxazino[3,4-b][1,3]benzoxazine]

Guidance literature:: Multi-step reaction with 5 steps

1.1: LiAlH₄

2.1: CBr₄; PPh₃ / CH₂Cl₂

3.1: 81 percent / K₂CO₃ / acetonitrile / 60 h / 80 - 90 °C

4.1: 89 percent / NaBH₄ / ethanol / 5 h / -10 - 0 °C

5.1: SnCl₄ / CH₂Cl₂ / 0.33 h / -78 °C

5.2: CH₂Cl₂ / 2 h / -78 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; carbon tetrabromide; tin(IV) chloride; potassium carbonate; triphenylphosphine; In ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jo061547k