N-benzyl-N-[4-(tert-butyl-dimethyl-silanyloxy)-1-(dimethyl-ethyl)-but-2-ynyl]-hydroxylamine

Base Information

Chemical Name:N-benzyl-N-[4-(tert-butyl-dimethyl-silanyloxy)-1-(dimethyl-ethyl)-but-2-ynyl]-hydroxylamine
CAS No.:294886-70-7
Molecular Formula:C₂₁H₃₅NO₂Si
Molecular Weight:361.6
Hs Code.:

Synonyms:N-benzyl-N-[4-(tert-butyl-dimethyl-silanyloxy)-1-(dimethyl-ethyl)-but-2-ynyl]-hydroxylamine

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Chemical Property of N-benzyl-N-[4-(tert-butyl-dimethyl-silanyloxy)-1-(dimethyl-ethyl)-but-2-ynyl]-hydroxylamine

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Technology Process of N-benzyl-N-[4-(tert-butyl-dimethyl-silanyloxy)-1-(dimethyl-ethyl)-but-2-ynyl]-hydroxylamine

There total 4 articles about N-benzyl-N-[4-(tert-butyl-dimethyl-silanyloxy)-1-(dimethyl-ethyl)-but-2-ynyl]-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 76782-82-6
tert-Butyldimethyl(prop-2-ynyloxy)silane

: 267238-05-1,144433-08-9,154020-46-9
(Z)-N-(2,2-dimethylpropylidene)-1-phenylmethanamine oxide

: 294886-70-7
N-benzyl-N-[4-(tert-butyl-dimethyl-silanyloxy)-1-(dimethyl-ethyl)-but-2-ynyl]-hydroxylamine

Guidance literature:: With triethylamine; zinc trifluoromethanesulfonate; In dichloromethane; at 23 ℃; for 7h;
DOI:10.1021/ol006095r

Reference yield:

: 622-32-2
(Z)-benzaldehyde oxime

: 294886-70-7
N-benzyl-N-[4-(tert-butyl-dimethyl-silanyloxy)-1-(dimethyl-ethyl)-but-2-ynyl]-hydroxylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / NaBH₃CN; aq. HCl / methanol / 3.5 h / 25 °C

2: 84 percent / MgSO₄ / diethyl ether / 15 h

3: 89 percent / Et₃N / Zn(OTf)2 / CH₂Cl₂ / 7 h / 23 °C

With hydrogenchloride; sodium cyanoborohydride; magnesium sulfate; triethylamine; zinc trifluoromethanesulfonate; In methanol; diethyl ether; dichloromethane; 1: Reduction / 2: Addition / 3: Addition;
DOI:10.1021/ol006095r

Reference yield:

: 100-52-7
benzaldehyde

: 294886-70-7
N-benzyl-N-[4-(tert-butyl-dimethyl-silanyloxy)-1-(dimethyl-ethyl)-but-2-ynyl]-hydroxylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / hydroxylamine hydrochloride; NaOH / ethanol; H₂O / 0.5 h / Heating

2: 94 percent / NaBH₃CN; aq. HCl / methanol / 3.5 h / 25 °C

3: 84 percent / MgSO₄ / diethyl ether / 15 h

4: 89 percent / Et₃N / Zn(OTf)2 / CH₂Cl₂ / 7 h / 23 °C

With hydrogenchloride; sodium hydroxide; hydroxylamine hydrochloride; sodium cyanoborohydride; magnesium sulfate; triethylamine; zinc trifluoromethanesulfonate; In methanol; diethyl ether; ethanol; dichloromethane; water; 1: Addition / 2: Reduction / 3: Addition / 4: Addition;
DOI:10.1021/ol006095r