methyl (2S,4R)-N-[4,5-dimethoxy-2-nitrobenzoyl]-4-(t-butyldimethylsilyl)-oxypyrrolidine-2-carboxylate

Base Information

Chemical Name:methyl (2S,4R)-N-[4,5-dimethoxy-2-nitrobenzoyl]-4-(t-butyldimethylsilyl)-oxypyrrolidine-2-carboxylate
CAS No.:757189-88-1
Molecular Formula:C₂₁H₃₂N₂O₈Si
Molecular Weight:468.579
Hs Code.:

Synonyms:methyl (2S,4R)-N-[4,5-dimethoxy-2-nitrobenzoyl]-4-(t-butyldimethylsilyl)-oxypyrrolidine-2-carboxylate

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Chemical Property of methyl (2S,4R)-N-[4,5-dimethoxy-2-nitrobenzoyl]-4-(t-butyldimethylsilyl)-oxypyrrolidine-2-carboxylate

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Technology Process of methyl (2S,4R)-N-[4,5-dimethoxy-2-nitrobenzoyl]-4-(t-butyldimethylsilyl)-oxypyrrolidine-2-carboxylate

There total 3 articles about methyl (2S,4R)-N-[4,5-dimethoxy-2-nitrobenzoyl]-4-(t-butyldimethylsilyl)-oxypyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 54431-30-0
1-(4,5-dimethoxy-2-nitrobenzoyl)-4-hydroxypyrrolidine-2-carboxylic acid methyl ester

: 757189-88-1
methyl (2S,4R)-N-[4,5-dimethoxy-2-nitrobenzoyl]-4-(t-butyldimethylsilyl)-oxypyrrolidine-2-carboxylate

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2004.06.013

Reference yield:

: 4998-07-6
4,5-dimethoxy-2-nitro-benzoic acid

: 757189-88-1
methyl (2S,4R)-N-[4,5-dimethoxy-2-nitrobenzoyl]-4-(t-butyldimethylsilyl)-oxypyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; DMF / benzene

2: 80 percent / triethylamine / tetrahydrofuran; H₂O / 20 °C

3: 92 percent / imidazole / CH₂Cl₂ / 20 °C

With 1H-imidazole; thionyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; benzene;
DOI:10.1016/j.bmc.2004.06.013

Reference yield:

: 29568-78-3
4,5-dimethoxy-2-nitrobenzoyl chloride

: 757189-88-1
methyl (2S,4R)-N-[4,5-dimethoxy-2-nitrobenzoyl]-4-(t-butyldimethylsilyl)-oxypyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / triethylamine / tetrahydrofuran; H₂O / 20 °C

2: 92 percent / imidazole / CH₂Cl₂ / 20 °C

With 1H-imidazole; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmc.2004.06.013