4-(4-(1H-indole-2-carboxamido)phenyl)-2-amino-1H-imidazol-3-ium chloride

Base Information

Chemical Name:4-(4-(1H-indole-2-carboxamido)phenyl)-2-amino-1H-imidazol-3-ium chloride
CAS No.:1574306-45-8
Molecular Formula:C₁₈H₁₅N₅O*ClH
Molecular Weight:353.811
Hs Code.:

Synonyms:4-(4-(1H-indole-2-carboxamido)phenyl)-2-amino-1H-imidazol-3-ium chloride

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Chemical Property of 4-(4-(1H-indole-2-carboxamido)phenyl)-2-amino-1H-imidazol-3-ium chloride

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Technology Process of 4-(4-(1H-indole-2-carboxamido)phenyl)-2-amino-1H-imidazol-3-ium chloride

There total 6 articles about 4-(4-(1H-indole-2-carboxamido)phenyl)-2-amino-1H-imidazol-3-ium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1574306-25-4
tert-butyl 4-(4-(1H-indole-2-carboxamido)phenyl)-2-amino-1H-imidazole-1-carboxylate

: 1574306-45-8
4-(4-(1H-indole-2-carboxamido)phenyl)-2-amino-1H-imidazol-3-ium chloride

Guidance literature:: With acetyl chloride; In ethanol; at 0 ℃; for 1h;
DOI:10.1016/j.ejmech.2013.12.034

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 1574306-45-8
4-(4-(1H-indole-2-carboxamido)phenyl)-2-amino-1H-imidazol-3-ium chloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap / acetonitrile / 5 h / 20 °C

2.1: hydrazine hydrate / ethyl [2]alcohol / 0.67 h / 120 °C / Microwave irradiation

3.1: methanol / 3 h / 20 °C

4.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 5 h / 20 °C

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / dichloromethane / 0.5 h / 20 °C

5.2: 24 h / 35 °C

6.1: acetyl chloride / ethanol / 1 h / 0 °C

With 4-methyl-morpholine; dmap; palladium on activated charcoal; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; acetyl chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl [2]alcohol; acetonitrile;
DOI:10.1016/j.ejmech.2013.12.034

Reference yield:

: 1574306-18-5
tert-butyl 2-amino-4-(4-aminophenyl)-1H-imidazole-1-carboxylate

: 1574306-45-8
4-(4-(1H-indole-2-carboxamido)phenyl)-2-amino-1H-imidazol-3-ium chloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / dichloromethane / 0.5 h / 20 °C

1.2: 24 h / 35 °C

2.1: acetyl chloride / ethanol / 1 h / 0 °C

With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetyl chloride; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2013.12.034