N-(4-chlorophenyl)-2-[((3-chloro-4-((methylthio)methyl)thiophen-2-yl)carbonyl)amino]-5-chlorobenzamide

Base Information

Chemical Name:N-(4-chlorophenyl)-2-[((3-chloro-4-((methylthio)methyl)thiophen-2-yl)carbonyl)amino]-5-chlorobenzamide
CAS No.:229338-82-3
Molecular Formula:C₂₀H₁₅Cl₃N₂O₂S₂
Molecular Weight:485.842
Hs Code.:

Synonyms:N-(4-chlorophenyl)-2-[((3-chloro-4-((methylthio)methyl)thiophen-2-yl)carbonyl)amino]-5-chlorobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-chlorophenyl)-2-[((3-chloro-4-((methylthio)methyl)thiophen-2-yl)carbonyl)amino]-5-chlorobenzamide

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Technology Process of N-(4-chlorophenyl)-2-[((3-chloro-4-((methylthio)methyl)thiophen-2-yl)carbonyl)amino]-5-chlorobenzamide

There total 12 articles about N-(4-chlorophenyl)-2-[((3-chloro-4-((methylthio)methyl)thiophen-2-yl)carbonyl)amino]-5-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 229342-64-7
3-chloro-N-(4-chloro-2-{[(4-chlorophenyl)amino]carbonyl}phenyl)-4-(chloromethyl)-2-thiophenecarboxamide

: 5188-07-8
sodium thiomethoxide

: 229338-82-3
N-(4-chlorophenyl)-2-[((3-chloro-4-((methylthio)methyl)thiophen-2-yl)carbonyl)amino]-5-chlorobenzamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2006.12.019

Reference yield: 68.0%

: 229338-82-3
N-(4-chlorophenyl)-2-[((3-chloro-4-((methylthio)methyl)thiophen-2-yl)carbonyl)amino]-5-chlorobenzamide

Guidance literature:

Reference yield:

: 175137-11-8
3-chloro-4-methyl-2-thiophenecarboxylic acid methyl ester

: 229338-82-3
N-(4-chlorophenyl)-2-[((3-chloro-4-((methylthio)methyl)thiophen-2-yl)carbonyl)amino]-5-chlorobenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 54 percent / SO₂Cl₂; benzoyl peroxide / 17 h / Heating

2: HOAc / 24 h / Heating

3: NaOH / dioxane; H₂O / 1 h

4: SOCl₂ / 6 h / Heating

5: 5.1 g / pyridine / CH₂Cl₂ / 0 - 20 °C

6: 68 percent / dimethylformamide / 16 h / 20 °C

With pyridine; sodium hydroxide; thionyl chloride; sulfuryl dichloride; acetic acid; dibenzoyl peroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.12.019