N-[2-([1,3]-dioxolan-2-yl-acetyl)-phenyl]pyridine-2-carboxylic acid amide

Base Information

• Chemical Name: N-[2-([1,3]-dioxolan-2-yl-acetyl)-phenyl]pyridine-2-carboxylic acid amide
• CAS No.: 178210-62-3
• Molecular Formula: C₁₇H₁₆N₂O₄
• Molecular Weight: 312.325
• Mol file: 178210-62-3.mol

Synonyms:N-[2-([1,3]-dioxolan-2-yl-acetyl)-phenyl]pyridine-2-carboxylic acid amide

Chemical Property of N-[2-([1,3]-dioxolan-2-yl-acetyl)-phenyl]pyridine-2-carboxylic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-([1,3]-dioxolan-2-yl-acetyl)-phenyl]pyridine-2-carboxylic acid amide

There total 2 articles about N-[2-([1,3]-dioxolan-2-yl-acetyl)-phenyl]pyridine-2-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-picolinoyl chloride hydrochloride (39901-94-5) + 2-(2-aminobenzoylmethyl)-1,3-dioxolane (178210-58-7) → N-[2-([1,3]-dioxolan-2-yl-acetyl)-phenyl]pyridine-2-carboxylic acid amide (178210-62-3)

Guidance literature:

With pyridine; dmap; In dichloromethane; 1.) 0 deg C, 1 h, 2.) 20 deg C, 3 h;

DOI:10.1016/0040-4020(96)00255-4

Reference yield:

2-(2-nitrobenzoylmethyl)-1,3-dioxolane (153813-82-2) → N-[2-([1,3]-dioxolan-2-yl-acetyl)-phenyl]pyridine-2-carboxylic acid amide (178210-62-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / H₂ / 5percent Pd-C / ethanol / 5 h / 760 Torr

2: 89 percent / pyridine, DMAP / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) 20 deg C, 3 h

With pyridine; dmap; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1016/0040-4020(96)00255-4

upstream raw materials:

2-picolinoyl chloride hydrochloride

2-(2-aminobenzoylmethyl)-1,3-dioxolane

2-(2-nitrobenzoylmethyl)-1,3-dioxolane