3-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(cyclohexylcarbamoyl)benzoic acid

Base Information

Chemical Name:3-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(cyclohexylcarbamoyl)benzoic acid
CAS No.:1374778-40-1
Molecular Formula:C₂₃H₂₁ClN₂O₄S
Molecular Weight:456.95
Hs Code.:

Synonyms:3-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(cyclohexylcarbamoyl)benzoic acid

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Chemical Property of 3-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(cyclohexylcarbamoyl)benzoic acid

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Technology Process of 3-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(cyclohexylcarbamoyl)benzoic acid

There total 4 articles about 3-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(cyclohexylcarbamoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1374779-78-8
C₂₄H₂₃ClN₂O₄S

: 1374778-40-1
3-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(cyclohexylcarbamoyl)benzoic acid

Guidance literature:: C₂₄H₂₃ClN₂O₄S; With water; potassium carbonate; In methanol; at 90 ℃; for 5h;

With hydrogenchloride; at 20 ℃; for 1h;

Reference yield:

: 10312-55-7
3-aminoterephthalic acid

: 1374778-40-1
3-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(cyclohexylcarbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 7 h / 60 °C

1.2: pH 8

1.3: pH 2

2.1: triethylamine / dichloromethane / 72 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / Reflux

4.1: N,N-dimethyl-formamide / 1.5 h / 20 °C

5.1: water; potassium carbonate / methanol / 5 h / 90 °C

5.2: 1 h / 20 °C

With oxalyl dichloride; sulfuric acid; water; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1374779-76-6
2-(3-chlorobenzo[b]thiophene-2-carboxamido)terephthalic acid-4-methyl ester

: 1374778-40-1
3-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(cyclohexylcarbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / Reflux

2.1: N,N-dimethyl-formamide / 1.5 h / 20 °C

3.1: water; potassium carbonate / methanol / 5 h / 90 °C

3.2: 1 h / 20 °C

With oxalyl dichloride; water; potassium carbonate; N,N-dimethyl-formamide; In methanol; dichloromethane; N,N-dimethyl-formamide;