10312-55-7Relevant articles and documents
Green reusable Pd nanoparticles embedded in phytochemical resins for mild hydrogenations of nitroarenes
Enneiymy, Mohamed,Le Drian, Claude,Becht, Jean-Michel
, p. 17383 - 17389 (2019)
A green chemical preparation of Pd nanoparticles (NPs) embedded in phytochemical resins using a plant extract from Pulicaria odora L. and PdCl2 under ambiant conditions is reported. Two batches of Pd NPs have been prepared: they present homogeneous sizes of respectively 2.2 nm and 3.2 nm depending on the preparation conditions. The Pd NPs were characterized by different techniques (TEM, HRTEM, XRD, XPS and BET) and have been successfully used for the reduction of nitroarenes in EtOH under H2 at atmospheric pressure at rt in the presence of only 5 mequiv. of Pd. Finally the Pd NPs embedded in resin particles were easily recovered by filtration and used at least seven times without significant loss in efficiency. The residual amount of palladium found in the reaction product is very low (0.6% of the initial amount). Therefore both preparation of the Pd NPs and their use for hydrogenations of nitroarenes are environmentally benign.
Defect Engineering into Metal-Organic Frameworks for the Rapid and Sequential Installation of Functionalities
Park, Hyojin,Kim, Seongwoo,Jung, Byunghyuck,Park, Myung Hwan,Kim, Youngjo,Kim, Min
, p. 1040 - 1047 (2018)
Postsynthetic treatments are well-known and important functionalization tools of metal-organic frameworks (MOFs). Herein, we have developed a practical and rapid postsynthetic ligand exchange (PSE) strategy using a defect-controlled MOF. An increase in the number of defects amounts to MOFs with enhanced rates of ligand exchange in a shorter time frame. An almost quantitative exchange was achieved by using the most defective MOFs. This PSE strategy is a straightforward method to introduce a functionality into MOFs including bulky or catalytically relevant moieties. Furthermore, some mechanistic insights into PSE were revealed, allowing for a sequential ligand exchange and the development of multifunctional MOFs with controlled ligand ratios.
Delivery of oxaliplatin to colorectal cancer cells by folate-targeted UiO-66-NH2
Hashemzadeh, Alireza,Amerizadeh, Forouzan,Asgharzadeh, Fereshteh,Darroudi, Majid,Avan, Amir,Hassanian, Seyed Mahdi,Landarani, Mohammad,Khazaei, Majid
, (2021)
Oxaliplatin is being used in different malignancies and several side effects are reported for patients taking Oxaliplatin, including peripheral neuropathy, nausea and vomiting, diarrhea, mouth sores, low blood counts, fatigue, loss of appetite, etc. Here we have developed a targeted anticancer drug delivery system based on folate-conjugated amine-functionalized UiO-66 for the delivery of oxaliplatin (OX). UiO-66-NH2 (U) and UiO-66-NH2–FA(FU) were pre-functionalized by the incorporation of folic acid (FA) into the structure via coordination of the carboxylate group of FA. The FTIR spectra of drug-loaded U and FU showed the presence of new carboxylic and aliphatic groups of OX and FA. Powder X-ray diffraction (PXRD) patterns were matched accordingly with the reference pattern and FESEM results showed semi-spherical particles (115–128 nm). The evaluated amounts of OX in U and FU were calculated 304.5 and 293 mg/g, respectively. The initial burst release of OX was 15.7% per hour for U(OX) and 10.8% per hour for FU(OX). The final release plateau gives 62.9% and 52.3% for U(OX) and FU(OX). To evaluate the application of the prepared delivery platform, they were tested on colorectal cancer cells (CT-26) via MTT assay, cell migration assay, and spheroid model. IC50 values obtained from MTT assay were 21.38, 95.50, and 18.20 μg/mL for OX, U(OX), and FU(OX), respectively. After three days of treatment, the CT26 spheroids at two doses of 500 and 50 μg/mL of U(OX) and FU(OX) showed volume reduction. Moreover, the oxidative behavior of the prepared systems within the cell was assessed by total thiol, malondialdehyde, and superoxide dismutase activity. The results showed that FU(OX) had higher efficacy in preventing the growth of CT-26 spheroid, and was more effective than oxaliplation in cell migration inhibition, and induced higher oxidative stress and apoptosis.
Tuning the release rate of volatile molecules by pore surface engineering in metal-organic frameworks
Chen, Hongwen,Chen, Huaqiang,Zhang, Bo,Jiang, Liming,Shen, Youqing,Fu, Engang,Zhao, Dan,Zhou, Zhuxian
supporting information, p. 1988 - 1992 (2021/03/24)
Encapsulation and controlled release of volatile molecules such as fragrances in a designed manner is important but challenging for the flavor and fragrance industry. Here, we report the tuning release of volatile molecules by postsynthetic modification of an amine-terminated metal-organic framework (MOF) MIL-101-NH2. By amidation, we obtained three MIL-101 MOFs, the trimethylacetamide-terminated TC-MIL-101, the benzamide-terminated BC-MIL-101, and the oxalic acid monoamide-terminated OC-MIL-101. All the MOFs can efficiently encapsulate volatile molecules. Moreover, we demonstrate that the release profile of volatiles can be widely tuned to sustain the release in several days to months and even over a year using different modified MIL-101 MOFs. We show that the release profiles are correlated with the binding energies between the guest volatiles and pores in MOFs. The pore diffusion and the synergistic transport are the rate-limiting step of the guest molecules from the modified MOFs.
