4-{1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-yl}phenylalanine

Base Information

Chemical Name:4-{1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-yl}phenylalanine
CAS No.:146490-19-9
Molecular Formula:C₁₁H₂₁B₁₀NO₂
Molecular Weight:307.403
Hs Code.:

4-{1,2-dicarba-closo-dodecaboran<sup>(12)</sup>-1-yl}phenylalanine

Synonyms:4-{1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-yl}phenylalanine

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Chemical Property of 4-{1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-yl}phenylalanine

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Technology Process of 4-{1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-yl}phenylalanine

There total 2 articles about 4-{1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-yl}phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 150174-87-1
diethyl p-{1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-yl}benzyl(formamido)malonate

: 146490-19-9
4-{1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-yl}phenylalanine

Guidance literature:: With hydrogenchloride; acetic acid; the borane-compd. is taken up in HCl and the mixt. allowed to reflux, after 20 min, acetic acid is introduced and reflux continued for 4 h; the mixt. is evaporated to dryness, the residue is crystallised from aq. EtOH;

Reference yield: 79.0%

: 7647-01-0,15364-23-5
hydrogenchloride

: 180193-11-7
C₂B₁₀H₁₁C₆H₄CH₂CH(CN)NC(C₆H₅)2

: 7664-93-9
sulfuric acid

: 146490-19-9
4-{1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-yl}phenylalanine

Guidance literature:: In benzene; stirring borane with excess 6 N HCl (room temp., 17 h), extn. of org. layer into ether, drying of combined org. layers, evapn., chromy. (SiO2, CHCl3/MeOH=10:1), stirring with 75% H2SO4 (95°C, 24 h); cooling in ice-water bath, washing (H2O), drying (vac.), HPLC (reversed C8-phase, MeOH/H2O=8.5:1.5); elem. anal.;
DOI:10.1021/ic9511229

Reference yield: 87.0%

: 146490-19-9
4-{1,2-dicarba-closo-dodecaboran⁽¹²⁾-1-yl}phenylalanine

: H⁽¹⁺⁾*K⁽¹⁺⁾*2(B₉H₇CHCC₆H₄CH₂CH(NH₂)COO)^(1-)=KH(B₉H₇CHCC₆H₄CH₂CH(NH₂)COO)2

Guidance literature:: With potassium hydroxide; In ethanol; the amino acid is added to a soln. of KOH in absolute EtOH under nitrogen, the mixt. is stirred at room temp. for 1 h, refluxed for 2 h and then cooled; EtOH is added to the mixt. which became turbid and then filtered, CO2 is bubbled through the filtrate and the milky suspn. is filtered, the filtrate is evaporated to dryness;