ethyl 11-<<(benzyl)(methyl)amino>methyl>-10,11-dihydro-α-oxo-5H-pyrrolo<2,1-c><1,4>benzodiazepine-10-acetate

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Chemical Name:ethyl 11-<<(benzyl)(methyl)amino>methyl>-10,11-dihydro-α-oxo-5H-pyrrolo<2,1-c><1,4>benzodiazepine-10-acetate
CAS No.:81729-77-3
Molecular Formula:C₂₅H₂₇N₃O₃
Molecular Weight:417.508
Hs Code.:

Synonyms:ethyl 11-<<(benzyl)(methyl)amino>methyl>-10,11-dihydro-α-oxo-5H-pyrrolo<2,1-c><1,4>benzodiazepine-10-acetate

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Chemical Property of ethyl 11-<<(benzyl)(methyl)amino>methyl>-10,11-dihydro-α-oxo-5H-pyrrolo<2,1-c><1,4>benzodiazepine-10-acetate

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Technology Process of ethyl 11-<<(benzyl)(methyl)amino>methyl>-10,11-dihydro-α-oxo-5H-pyrrolo<2,1-c><1,4>benzodiazepine-10-acetate

There total 10 articles about ethyl 11-<<(benzyl)(methyl)amino>methyl>-10,11-dihydro-α-oxo-5H-pyrrolo<2,1-c><1,4>benzodiazepine-10-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 4755-77-5
Ethyl oxalyl chloride

: 81729-48-8
11-<<(benzyl)(methyl)amino>methyl>-10,11-dihydro-5H-pyrrolo<2,1-c><1,4>benzodiazepine

: 81729-77-3
ethyl 11-<<(benzyl)(methyl)amino>methyl>-10,11-dihydro-α-oxo-5H-pyrrolo<2,1-c><1,4>benzodiazepine-10-acetate

Guidance literature:: With triethylamine; In tetrahydrofuran; Ambient temperature; overnight;
DOI:10.1002/jhet.5570200626

Reference yield:

: 88-72-2
1-methyl-2-nitrobenzene

: 81729-77-3
ethyl 11-<<(benzyl)(methyl)amino>methyl>-10,11-dihydro-α-oxo-5H-pyrrolo<2,1-c><1,4>benzodiazepine-10-acetate

Guidance literature:: Multi-step reaction with 9 steps

1: 1. Br₂ / Ambient temperature; 1. CCl₄, irradiation, reflux, 4h; 2. r.t., overnight

2: 12N hydrochloric acid / ethanol / Ambient temperature; overnight

3: 86 percent / acetic acid / 0.08 h / Heating

4: 64 percent / HCl (g) / diethyl ether / 10 degC, 3h, then r.t., overnight

5: 83 percent / H₂O / 1 h / 80 °C

6: 87 percent / triethylamine / toluene / 6 h / 95 °C / r.t., overnight

7: H₂ / PtO₂ / ethyl acetate / 3.5 h / Ambient temperature

8: H₂ / PtO₂ / acetic acid; ethyl acetate / 1.5 h / Ambient temperature

9: 90 percent / triethylamine / tetrahydrofuran / Ambient temperature; overnight

With hydrogenchloride; hydrogen; bromine; triethylamine; platinum(IV) oxide; In tetrahydrofuran; diethyl ether; ethanol; water; acetic acid; ethyl acetate; toluene;
DOI:10.1002/jhet.5570200626

Reference yield:

: 1904-78-5
2-nitrobenzylamine

: 81729-77-3
ethyl 11-<<(benzyl)(methyl)amino>methyl>-10,11-dihydro-α-oxo-5H-pyrrolo<2,1-c><1,4>benzodiazepine-10-acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / acetic acid / 0.08 h / Heating

2: 64 percent / HCl (g) / diethyl ether / 10 degC, 3h, then r.t., overnight

3: 83 percent / H₂O / 1 h / 80 °C

4: 87 percent / triethylamine / toluene / 6 h / 95 °C / r.t., overnight

5: H₂ / PtO₂ / ethyl acetate / 3.5 h / Ambient temperature

6: H₂ / PtO₂ / acetic acid; ethyl acetate / 1.5 h / Ambient temperature

7: 90 percent / triethylamine / tetrahydrofuran / Ambient temperature; overnight

With hydrogenchloride; hydrogen; triethylamine; platinum(IV) oxide; In tetrahydrofuran; diethyl ether; water; acetic acid; ethyl acetate; toluene;
DOI:10.1002/jhet.5570200626