2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-4-yl]benzylsulphanyl}ethanol

Base Information

Chemical Name:2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-4-yl]benzylsulphanyl}ethanol
CAS No.:912347-03-6
Molecular Formula:C₄₃H₆₄N₂O₇S₂Si
Molecular Weight:813.208
Hs Code.:

2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-4-yl]benzylsulphanyl}ethanol

Synonyms:2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-4-yl]benzylsulphanyl}ethanol

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Chemical Property of 2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-4-yl]benzylsulphanyl}ethanol

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Technology Process of 2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-4-yl]benzylsulphanyl}ethanol

There total 5 articles about 2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-4-yl]benzylsulphanyl}ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911855-71-5
6-[(3R,4R,5S)-4-(4-chloromethyl-phenyl)-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine

: 60-24-2
2-hydroxyethanethiol

: 912347-03-6
2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-4-yl]benzylsulphanyl}ethanol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 912347-03-6
2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-4-yl]benzylsulphanyl}ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / water; ethyl acetate / 14 h / 20 °C

2: methanesulfonyl chloride; tetrabutyl-ammonium chloride; triethylamine / dichloromethane / 6 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

With tetrabutyl-ammonium chloride; sodium carbonate; potassium carbonate; methanesulfonyl chloride; triethylamine; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 911855-73-7
(4-{(3R,4R,5S)-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxy-piperidin-4-yl}-phenyl)-methanol

: 912347-03-6
2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-4-yl]benzylsulphanyl}ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / water; ethyl acetate / 14 h / 20 °C

2: methanesulfonyl chloride; tetrabutyl-ammonium chloride; triethylamine / dichloromethane / 6 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

With tetrabutyl-ammonium chloride; sodium carbonate; potassium carbonate; methanesulfonyl chloride; triethylamine; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;