6-[(3R,4R,5S)-4-[4-(2-methoxy-ethylsulphanylmethyl)-phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Base Information

Chemical Name:6-[(3R,4R,5S)-4-[4-(2-methoxy-ethylsulphanylmethyl)-phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine
CAS No.:912347-02-5
Molecular Formula:C₄₄H₆₆N₂O₇S₂Si
Molecular Weight:827.235
Hs Code.:

6-[(3R,4R,5S)-4-[4-(2-methoxy-ethylsulphanylmethyl)-phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Synonyms:6-[(3R,4R,5S)-4-[4-(2-methoxy-ethylsulphanylmethyl)-phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine

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Chemical Property of 6-[(3R,4R,5S)-4-[4-(2-methoxy-ethylsulphanylmethyl)-phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine

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Technology Process of 6-[(3R,4R,5S)-4-[4-(2-methoxy-ethylsulphanylmethyl)-phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine

There total 5 articles about 6-[(3R,4R,5S)-4-[4-(2-methoxy-ethylsulphanylmethyl)-phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 912347-03-6
2-{4-[(3R,4R,5S)-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxypiperidin-4-yl]benzylsulphanyl}ethanol

: 74-88-4
methyl iodide

: 912347-02-5
6-[(3R,4R,5S)-4-[4-(2-methoxy-ethylsulphanylmethyl)-phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 17h;

Reference yield:

: 911855-72-6
{4-[(3R,4R,5S)-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxy-piperidin-4-yl]-phenyl}-methanol

: 912347-02-5
6-[(3R,4R,5S)-4-[4-(2-methoxy-ethylsulphanylmethyl)-phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl-ammonium chloride; triethylamine / dicloromethane / 66 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 - 18 h / 20 °C

3: sodium hydride / tetrahydrofuran / 17 h / 0 - 20 °C

With tetrabutyl-ammonium chloride; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; dicloromethane; N,N-dimethyl-formamide;

Reference yield:

: 911855-73-7
(4-{(3R,4R,5S)-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxy-piperidin-4-yl}-phenyl)-methanol

: 912347-02-5
6-[(3R,4R,5S)-4-[4-(2-methoxy-ethylsulphanylmethyl)-phenyl]-1-(toluene-4-sulphonyl)-5-triisopropylsilanyloxy-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / water; ethyl acetate / 14 h / 20 °C

2: tetrabutyl-ammonium chloride; triethylamine / dicloromethane / 66 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 4 - 18 h / 20 °C

4: sodium hydride / tetrahydrofuran / 17 h / 0 - 20 °C

With tetrabutyl-ammonium chloride; sodium hydride; sodium carbonate; potassium carbonate; triethylamine; In tetrahydrofuran; dicloromethane; water; ethyl acetate; N,N-dimethyl-formamide;