PYRIDINES

Base Information

• Chemical Name: PYRIDINES
• CAS No.: 121307-80-0
• Molecular Formula: C6H4F3NS
• Molecular Weight: 179.166
• Hs Code.: 2933399090
• Mol file: 121307-80-0.mol

Synonyms:PYRIDINES;3-Fluoro-5-nitro-2-hydroxypyridine;3-Fluoro-5-nitropyridin-2-ol;5-Nitropyridin-2-ylboronic acid;6-(4-Methoxybenzylcarbamoyl)pyridine-3-boronic acid;N-4-Methoxybenzyl 5-borono-2-pyridinecarboxamide;Methyl 2-hydroxy-3-nitro-5-pyridinecarboxylate;Methyl 6-hydroxy-5-nitronicotinate

Chemical Property of PYRIDINES

Chemical Property:

• Vapor Pressure: 0.875mmHg at 25°C
• Refractive Index: 1.494
• Boiling Point: 187.3 °C at 760 mmHg
• Flash Point: 67.1 °C
• PSA: 51.69000
• Density: 1.391 g/cm³
• LogP: 2.38910
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-(Trifluoromethyl)pyridine-2-thiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PYRIDINES

There total 2 articles about PYRIDINES which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-((6-(trifluoromethyl)pyridin-2-yl)thio)propanoate → 6-(trifluoromethyl)pyridine-2-thiol (121307-80-0)

Guidance literature:

With sodium methylate; In methanol; at 80 ℃; for 2h; Cooling with ice;

Reference yield:

2-chloro-6-trifluoromethylpyridine (39890-95-4) → 6-(trifluoromethyl)pyridine-2-thiol (121307-80-0)

Guidance literature:

With Methyl 3-mercaptopropionate; sodium methylate; Yield given. Multistep reaction; 1) DMF, 1 to 1.5 h heating on a steam bath, 2) MeOH, 1 h, reflux;

DOI:10.1002/prac.19923340204

Reference yield: 86.0%

6-(trifluoromethyl)pyridine-2-thiol (121307-80-0) + dicyclohexyl-carbodiimide (538-75-0) → N,N'-dicyclohexyl-1,1-bis((6-(trifluoromethyl)pyridin-2-yl)thio)methanediamine

Guidance literature:

With C₃₂H₄₄N₆P₂Se₂Ti₂; In toluene; at 25 ℃; for 3h; chemoselective reaction; Glovebox; Schlenk technique;

DOI:10.1021/acs.inorgchem.8b01766

upstream raw materials:

2-chloro-6-trifluoromethylpyridine

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