6-{[2-(benzylamino)ethyl](methylsulfonyl)amino}-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

Base Information

Chemical Name:6-{[2-(benzylamino)ethyl](methylsulfonyl)amino}-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide
CAS No.:1333224-53-5
Molecular Formula:C₃₂H₃₀FN₃O₄S
Molecular Weight:571.672
Hs Code.:

Synonyms:6-{[2-(benzylamino)ethyl](methylsulfonyl)amino}-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

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Chemical Property of 6-{[2-(benzylamino)ethyl](methylsulfonyl)amino}-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

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Technology Process of 6-{[2-(benzylamino)ethyl](methylsulfonyl)amino}-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

There total 10 articles about 6-{[2-(benzylamino)ethyl](methylsulfonyl)amino}-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1333225-24-3
6-{[2-(benzylamino)ethyl](methylsulfonyl)amino}-2-(4-fluorophenyl)-5-phenyl-1-benzofuran-3-carboxylic acid

: 593-51-1
methylamine hydrochloride

: 1333224-53-5
6-{[2-(benzylamino)ethyl](methylsulfonyl)amino}-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

Guidance literature:: 6-{[2-(benzylamino)ethyl](methylsulfonyl)amino}-2-(4-fluorophenyl)-5-phenyl-1-benzofuran-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.5h;

methylamine hydrochloride; With triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 98-80-6
phenylboronic acid

: 1333224-53-5
6-{[2-(benzylamino)ethyl](methylsulfonyl)amino}-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: potassium phosphate tribasic trihydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere

2: water; iron; ammonium chloride / tetrahydrofuran; methanol / 4 h / Reflux

3: pyridine / dichloromethane / 20 °C

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

5: triethylamine / dichloromethane / 20 °C

6: triethylamine / acetonitrile / 60 °C

7: water; lithium hydroxide / 1,4-dioxane / 2 h / Reflux

8: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h

With pyridine; potassium phosphate tribasic trihydrate; water; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 691857-51-9
ethyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

: 1333224-53-5
6-{[2-(benzylamino)ethyl](methylsulfonyl)amino}-2-(4-fluorophenyl)-N-methyl-5-phenyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: potassium phosphate tribasic trihydrate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere

2: water; iron; ammonium chloride / tetrahydrofuran; methanol / 4 h / Reflux

3: pyridine / dichloromethane / 20 °C

4: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

5: triethylamine / dichloromethane / 20 °C

6: triethylamine / acetonitrile / 60 °C

7: water; lithium hydroxide / 1,4-dioxane / 2 h / Reflux

8: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h

With pyridine; potassium phosphate tribasic trihydrate; water; iron; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;