(-)-(R)-α-phenyl-α-trifluoromethylglycine

Base Information

Chemical Name:(-)-(R)-α-phenyl-α-trifluoromethylglycine
CAS No.:1281952-37-1
Molecular Formula:C₉H₈F₃NO₂
Molecular Weight:219.163
Hs Code.:

Synonyms:(-)-(R)-α-phenyl-α-trifluoromethylglycine

Suppliers and Price of (-)-(R)-α-phenyl-α-trifluoromethylglycine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-(R)-α-phenyl-α-trifluoromethylglycine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-(R)-α-phenyl-α-trifluoromethylglycine

There total 3 articles about (-)-(R)-α-phenyl-α-trifluoromethylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1280716-77-9
(-)-(R)-5-phenyl-5-(trifluoromethyl)hydantoin

: 1281952-37-1
(-)-(R)-α-phenyl-α-trifluoromethylglycine

Guidance literature:: (-)-(R)-5-phenyl-5-(trifluoromethyl)hydantoin; With barium hydroxide octahydrate; In water; for 72h; Reflux;

With sulfuric acid; In water; at 20 ℃; pH=1;

With ammonium hydroxide; In water;
DOI:10.1016/j.tetasy.2010.11.029

Reference yield:

: 434-45-7
2,2,2-Trifluoroacetophenone

: 1281952-37-1
(-)-(R)-α-phenyl-α-trifluoromethylglycine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol; water / 38 h / 110 - 120 °C / Autoclave

2.1: ethanol / 48 h / -15 - 30 °C / Resolution of racemate; Auto-seeded programmed polythermic preferential crystallization

3.1: barium hydroxide octahydrate / water / 72 h / Reflux

3.2: 20 °C / pH 1

3.3: DOWEX 50WX₈-100 (H⁺ form)

With barium hydroxide octahydrate; In ethanol; water; 1.1: Bucherer-Bergs reaction;
DOI:10.1016/j.tetasy.2010.11.029

Reference yield:

: 783-61-9
5-Phenyl-5-(trifluormethyl)imidazolidin-2,4-dion

: 1281952-37-1
(-)-(R)-α-phenyl-α-trifluoromethylglycine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 48 h / -15 - 30 °C / Resolution of racemate; Auto-seeded programmed polythermic preferential crystallization

2.1: barium hydroxide octahydrate / water / 72 h / Reflux

2.2: 20 °C / pH 1

2.3: DOWEX 50WX₈-100 (H⁺ form)

With barium hydroxide octahydrate; In ethanol; water;
DOI:10.1016/j.tetasy.2010.11.029