N-<3--N-(tert-butyloxycarbonyl)amino>-4-methoxyphenyl>-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide

Base Information

Chemical Name:N-<3--N-(tert-butyloxycarbonyl)amino>-4-methoxyphenyl>-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide
CAS No.:170229-87-5
Molecular Formula:C₃₃H₃₉N₅O₅
Molecular Weight:585.703
Hs Code.:

N-<3-<N-<2-(dimethylamino)ethyl>-N-(tert-butyloxycarbonyl)amino>-4-methoxyphenyl>-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide

Synonyms:N-<3--N-(tert-butyloxycarbonyl)amino>-4-methoxyphenyl>-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide

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Chemical Property of N-<3--N-(tert-butyloxycarbonyl)amino>-4-methoxyphenyl>-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide

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Technology Process of N-<3--N-(tert-butyloxycarbonyl)amino>-4-methoxyphenyl>-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide

There total 7 articles about N-<3--N-(tert-butyloxycarbonyl)amino>-4-methoxyphenyl>-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 170229-86-4
N,N-dimethyl-N'-(tert-butyloxycarbonyl)-N'-(5-amino-2-methoxyphenyl)ethylenediamine

: 165381-86-2
2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-biphenyl-4-carbonyl chloride

: 170229-87-5
N-<3--N-(tert-butyloxycarbonyl)amino>-4-methoxyphenyl>-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jm970457s

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 170229-87-5
N-<3--N-(tert-butyloxycarbonyl)amino>-4-methoxyphenyl>-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 39 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

2: 80 percent / H₂ / 10 percent Pd/C / ethanol / Ambient temperature

3: 57 percent / aq. NaOH / tetrahydrofuran / Ambient temperature

With sodium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm970457s

Reference yield:

: 170229-83-1
N,N-dimethyl-N'-(2-methoxyphenyl)ethylenediamine

: 170229-87-5
N-<3--N-(tert-butyloxycarbonyl)amino>-4-methoxyphenyl>-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 49 percent / conc. H₂SO₄, KNO₃ / H₂O / 4 h / Ambient temperature

2: 39 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

3: 80 percent / H₂ / 10 percent Pd/C / ethanol / Ambient temperature

4: 57 percent / aq. NaOH / tetrahydrofuran / Ambient temperature

With sodium hydroxide; sulfuric acid; hydrogen; potassium nitrate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm970457s