170229-83-1Relevant academic research and scientific papers
Microwave-promoted mono-N-alkylation of aromatic amines in water: A new efficient and green method for an old and problematic reaction
Marzaro, Giovanni,Guiotto, Adriano,Chilin, Adriana
supporting information; experimental part, p. 774 - 776 (2010/04/23)
A greener improvement to direct mono-N-alkylation of aromatic amines by alkyl halides was achieved using microwave irradiation in water without any catalyst.
The selective 5-HT(1B) receptor inverse agonist 1-methyl-5-[[2'-methyl- 4'(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7- tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function bo
Gaster, Laramie M.,Blaney, Frank E.,Davies, Susannah,Duckworth, D. Malcolm,Ham, Peter,Jenkins, Sarah,Jennings, Andrew J.,Joiner, Graham F.,King, Frank D.,Mulholland, Keith R.,Wyman, Paul A.,Hagan, Jim J.,Hatcher, Jon,Jones, Brian J.,Middlemiss, Derek N.,Price, Gary W.,Riley, Graham,Roberts, Claire,Routledge, Carol,Selkirk, Julie,Slade, Paula D.
, p. 1218 - 1235 (2007/10/03)
5-HT1 receptors are members of the G-protein-coupled receptor superfamily and are negatively linked to adenylyl cyclase activity. The human 5-HT(1B) and 5-HT(1D) receptors (previously known as 5-HT(1Dβ) and 5- HT(1Dα), respectively), although e
N-N-disubstituted alkenamides and phenylalkenamides
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, (2008/06/13)
Compounds of the formula STR1 where n is 0 or 1, R is alkyl, phenyl or R4 -substituted phenyl, R2 and R3 are, independently, alkyl or R2 and R3 together with N is STR2 m is 1, 2 or 3, R1 and R4 are, independently hydrogen, halo, alkyl or alkoxy, and R5 is hydrogen or alkyl of 1 to 6 carbon atoms or their pharmaceutically acceptable salts are useful as anti-diabetic agents, in particular, as hypoglycemic agents or inhibitors of post-prandial hypoglycemia.
