(2R,3S,4R)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-3-triethylsilanyloxy-pentanal

Base Information

Chemical Name:(2R,3S,4R)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-3-triethylsilanyloxy-pentanal
CAS No.:160238-49-3
Molecular Formula:C₂₁H₃₆O₄Si
Molecular Weight:380.6
Hs Code.:

Synonyms:(2R,3S,4R)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-3-triethylsilanyloxy-pentanal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,4R)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-3-triethylsilanyloxy-pentanal

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Technology Process of (2R,3S,4R)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-3-triethylsilanyloxy-pentanal

There total 5 articles about (2R,3S,4R)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-3-triethylsilanyloxy-pentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 160238-48-2
(2R,3S,4R)-N-methoxy-5-(4-methoxybenzyl)oxy-N,2,4-trimethyl-3-(triethylsilyl)oxy-pentanamide

: 160238-49-3
(2R,3S,4R)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-3-triethylsilanyloxy-pentanal

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -78 ℃; for 1.33333h;
DOI:10.1016/0040-4020(96)00811-3

Reference yield:

: 160238-45-9
(2S)-3-(4-methoxybenzyloxy)-2-methyl-1-propanol

: 160238-49-3
(2R,3S,4R)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-3-triethylsilanyloxy-pentanal

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) CH₂Cl₂, from -78 to 0 deg C, 1 h

2: 1.) n-Bu₂BOTf, Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, a) -78 deg C, 3 h, b) 0 deg C, 2 h

3: 1.) Me₃Al / 1.) THF, hexane, RT, 1 h, 2.) THF, hexane, RT, 12 h

4: imidazole / dimethylformamide / 15 h / Ambient temperature

5: 99 percent / DIBAL-H / tetrahydrofuran; hexane / 1.33 h / -78 °C

With 1H-imidazole; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00811-3

Reference yield:

: 160238-46-0
(2R)-3-(4-methoxybenzyloxy)-2-methyl-1-propanal

: 160238-49-3
(2R,3S,4R)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-3-triethylsilanyloxy-pentanal

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-Bu₂BOTf, Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, a) -78 deg C, 3 h, b) 0 deg C, 2 h

2: 1.) Me₃Al / 1.) THF, hexane, RT, 1 h, 2.) THF, hexane, RT, 12 h

3: imidazole / dimethylformamide / 15 h / Ambient temperature

4: 99 percent / DIBAL-H / tetrahydrofuran; hexane / 1.33 h / -78 °C

With 1H-imidazole; di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(96)00811-3